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Literature summary for 3.4.24.80 extracted from

  • Fan, L.; Liu, L.; Zhu, C.; Zhu, Q.; Lu, S.; Liu, P.
    MT1-MMP inhibits the activity of Bst-2 via their cytoplasmic domains dependent interaction (2016), Int. J. Mol. Sci., 17, 818 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Cloned(Commentary)

Cloned (Comment) Organism
gene MMP14, transient recombinant overexpression of MT1-MMP in HT-1080 cells, quantitative expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bone marrow stromal cell antigen 2 best-2, interaction with MT1-MMP via the cytoplasmic tails of both. Bst-2 inhibits the release of virus from infectious cells and this inhibition can be reversed by MT1-MMP. Bst-2 tetherin activity is blocked by MT1-MMP Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-type matrix metalloproteinase 1 is a type I membrane protein Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Type I collagen + H2O Homo sapiens
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 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50281
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no activity in Canis familiaris
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 MDCK cells
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Source Tissue

Source Tissue Comment Organism Textmining
HT-1080 cell low enzyme expression Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Type I collagen + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
membrane type-1 matrix metalloproteinase
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 Homo sapiens
MMP14
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 Homo sapiens
MT1-MMP
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 Homo sapiens

General Information

General Information Comment Organism
evolution membrane-type matrix metalloproteinase 1 (MT1-MMP, also MMP14) is a type I membrane protein belonging to the MT-MMP family Homo sapiens
physiological function membrane type-1 matrix metalloproteinase (MT1-MMP) plays a pivotal role in cellular growth and migration by activating proMMP-2 into active MMP2. MT1-MMP inhibits the tetherin activity of Bst-2 (bone marrow stromal cell antigen 2), a type II membrane protein, by interacting with Bst-2, not via downregulation of Bst-2. The cytoplasmic domains of both Bst-2 and MT1-MMP play critical roles within this interaction. Bst-2 inhibits MT1-MMP activity through their interaction resulting in a decrease of proMMP2 activation Homo sapiens