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Literature summary for 3.4.24.80 extracted from

  • Gaublomme, D.; Buyens, T.; De Groef, L.; Stakenborg, M.; Janssens, E.; Ingvarsen, S.; Porse, A.; Behrendt, N.; Moons, L.
    Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells (2014), J. Neurochem., 129, 966-979.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
DX-2400 enzyme activity is inhibited with 65.8 nM or 658 nM of the enzyme function-blocking antibody DX-2400 Mus musculus
GM6001
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-MMP-2 + H2O Mus musculus
-
MMP-2 + MMP-2 propeptide
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P53690
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glial cell
-
Mus musculus
-
retinal ganglion cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
Mus musculus ?
-
?
pro-MMP-2 + H2O
-
Mus musculus MMP-2 + MMP-2 propeptide
-
?

Synonyms

Synonyms Comment Organism
membrane type 1 matrix metalloproteinase
-
Mus musculus
MT1-MMP
-
Mus musculus

General Information

General Information Comment Organism
physiological function membrane type 1 matrix metalloproteinase-dependent activation of MMP-2 is required for optimal neurite outgrowth Mus musculus