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Literature summary for 3.4.24.80 extracted from

  • Tassone, E.; Valacca, C.; Mignatti, P.
    Membrane-type 1 matrix metalloproteinase downregulates fibroblast growth factor-2 binding to the cell surface and intracellular signaling (2015), J. Cell. Physiol., 230, 366-377.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane proteinase Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
 x * 58000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibroblast growth factor receptor-1 + H2O Homo sapiens
-
 ?
-
 ?
fibroblast growth factor receptor-4 + H2O Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens the enzyme does not degrade fibroblast growth factor-2 or fibroblast growth factor receptor-2 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50281
-
-

Source Tissue

Source Tissue Comment Organism Textmining
KNS-42 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
Res-186 cell
-
 Homo sapiens
-
Res-259 cell
-
 Homo sapiens
-
SF-188 cell
-
 Homo sapiens
-
UW-479 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibroblast growth factor receptor-1 + H2O
-
 Homo sapiens ?
-
 ?
fibroblast growth factor receptor-4 + H2O
-
 Homo sapiens ?
-
 ?
additional information the enzyme does not degrade fibroblast growth factor-2 or fibroblast growth factor receptor-2 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 58000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
membrane-type I matrix metalloproteinase
-
 Homo sapiens
MT1-MMP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function in tumor cells the enzyme downregulates fibroblast growth factor-2 signaling by reducing the amount of fibroblast growth factor-2 signaling bound to the cell surface with high and low affinity Homo sapiens