Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DX2400 | human monoclonal antibody | Rattus norvegicus | |
tissue inhibitor of metalloproteinases-2 | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Laminin + H2O | Rattus norvegicus | - |
? | - |
? | |
neuronal glial antigen 2 + H2O | Rattus norvegicus | three (210, 160, and 51-52 kDa) major cleavage products are formed | ? | - |
? | |
pro-MMP-2 + H2O | Rattus norvegicus | - |
MMP-2 + MMP-2 propeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q10739 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Schwann cell | - |
Rattus norvegicus | - |
sciatic nerve | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7-methoxycoumarin-4-yl)acetyl-L-Pro-Leu-Gly-Leu-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-Ala-Arg-NH2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
Gelatin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Laminin + H2O | - |
Rattus norvegicus | ? | - |
? | |
neuronal glial antigen 2 + H2O | three (210, 160, and 51-52 kDa) major cleavage products are formed | Rattus norvegicus | ? | - |
? | |
pro-MMP-2 + H2O | - |
Rattus norvegicus | MMP-2 + MMP-2 propeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
membrane type 1 matrix metalloproteinase | - |
Rattus norvegicus |
MT1-MMP/MMP-14 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | MT1-MMP inhibition restores sensory axon regeneration and attenuates hypersensitivity caused by peripheral nerve injury | Rattus norvegicus |
physiological function | both neuronal glial antigen 2 shedding and axonal growth depend on the pericellular remodeling executed by MT1-MMP/MMP-14 | Rattus norvegicus |