Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.80 extracted from

  • Eisenach, P.A.; Correa de Sampaio, P.; Murphy, G.; Roghi, C.
    Membrane-type 1 matrix metalloproteinase (MT1-MMP) ubiquitination at K581 increases cellular invasion through type-I collagen (2012), J. Biol. Chem., 287, 11533-11545.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Protein Variants

Protein Variants Comment Organism
K581R ubiquitination-deficient mutant Homo sapiens
Y573A the mutant displays significant reduction of ubiquitination Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
 x * 72000, mono-ubiquitinated full-length enzyme, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylated at Y573 and T567 Homo sapiens
ubiquitination MT1-MMP is mono-ubiquitinated intracellularly at K581 within the short intracellular domain by NEDD-4. This post-translational modification is involved in MT1-MMP trafficking as well as in modulating cellular invasion through type-I collagen matrices. Ubiquitination is regulated by Src-mediated phosphorylation of MT1-MMP Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
type-I collagen + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 72000, mono-ubiquitinated full-length enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
membrane type 1 matrix metalloproteinase
-
 Homo sapiens
MMP14
-
 Homo sapiens
MT1-MMP
-
 Homo sapiens