Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GM6001 | broad-spectrum matrix metalloproteinase inhibitor, strong inhibition | Homo sapiens | |
marimastat | strong inhibition | Homo sapiens | |
additional information | not inhibited by E-64 and aprotinin | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | - |
Homo sapiens | - |
ECRF cell | - |
Homo sapiens | - |
endothelial cell | - |
Homo sapiens | - |
HUVEC cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
endoglin + H2O | MMP-14 cleaves membrane-bound endoglin at a site in close proximity to the transmembrane domain between Gly586-Leu-587 | Homo sapiens | soluble endoglin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-14 | - |
Homo sapiens |
membrane-type 1 matrix metalloproteinase | - |
Homo sapiens |
MMP14 | - |
Homo sapiens |
MT1-MMP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | in endothelial cells, MMP-14 is the main endoglin shedding protease | Homo sapiens |