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Literature summary for 3.4.24.80 extracted from

  • Chiu, H.C.; Lu, Y.T.; Chin, Y.T.; Tu, H.P.; Chiang, C.Y.; Gau, C.H.; Nieh, S.; Fu, E.
    Cyclosporine A inhibits the expression of membrane type-I matrix metalloproteinase in gingiva (2009), J. Periodontal Res., 44, 338-347.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
TIMP-2
-
Homo sapiens
TIMP-2
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane membrane type-I MMP, like the other five membrane type MMPs, differs from other MMPs in that it has a transmembrane domain that localizes the enzyme to the plasma membrane in addition to the three basic domains that characterize all other MMPs Homo sapiens 5886
-
plasma membrane membrane type-I MMP, like the other five membrane type MMPs, differs from other MMPs in that it has a transmembrane domain that localizes the enzyme to the plasma membrane in addition to the three basic domains that characterize all other MMPs Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-MMP-2 + H2O Homo sapiens
-
MMP-2 + MMP-2 propeptide
-
?
pro-MMP-2 + H2O Rattus norvegicus
-
MMP-2 + MMP-2 propeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gingiva quantitative determination of content of membrane type-I MMP, TIMP-2 and MMP-2 mRNA and proteins Rattus norvegicus
-
gingival fibroblast quantitative determination of content of membrane type-I MMP, TIMP-2 and MMP-2 mRNA and proteins Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-MMP-2 + H2O
-
Homo sapiens MMP-2 + MMP-2 propeptide
-
?
pro-MMP-2 + H2O
-
Rattus norvegicus MMP-2 + MMP-2 propeptide
-
?

Subunits

Subunits Comment Organism
More membrane type-I MMP, like the other five membrane type MMPs, differs from other MMPs in that it has a transmembrane domain that localizes the enzyme to the plasma membrane in addition to the three basic domains that characterize all other MMPs Homo sapiens
More membrane type-I MMP, like the other five membrane type MMPs, differs from other MMPs in that it has a transmembrane domain that localizes the enzyme to the plasma membrane in addition to the three basic domains that characterize all other MMPs Rattus norvegicus

Synonyms

Synonyms Comment Organism
membrane type-I matrix metalloproteinase
-
Homo sapiens
membrane type-I matrix metalloproteinase
-
Rattus norvegicus
membrane type-I MMP
-
Homo sapiens
membrane type-I MMP
-
Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens cyclosporine A inhibits expression of membrane-type I MMP in gingiva down
Rattus norvegicus cyclosporine A inhibits expression of membrane-type I MMP, but not of TIMP-2, in gingiva. Transcription of MMP-2 is unaffected, but translation is inhibited down