Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TIMP-2 | - |
Homo sapiens | |
TIMP-2 | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | membrane type-I MMP, like the other five membrane type MMPs, differs from other MMPs in that it has a transmembrane domain that localizes the enzyme to the plasma membrane in addition to the three basic domains that characterize all other MMPs | Homo sapiens | 5886 | - |
plasma membrane | membrane type-I MMP, like the other five membrane type MMPs, differs from other MMPs in that it has a transmembrane domain that localizes the enzyme to the plasma membrane in addition to the three basic domains that characterize all other MMPs | Rattus norvegicus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-MMP-2 + H2O | Homo sapiens | - |
MMP-2 + MMP-2 propeptide | - |
? | |
pro-MMP-2 + H2O | Rattus norvegicus | - |
MMP-2 + MMP-2 propeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gingiva | quantitative determination of content of membrane type-I MMP, TIMP-2 and MMP-2 mRNA and proteins | Rattus norvegicus | - |
gingival fibroblast | quantitative determination of content of membrane type-I MMP, TIMP-2 and MMP-2 mRNA and proteins | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-MMP-2 + H2O | - |
Homo sapiens | MMP-2 + MMP-2 propeptide | - |
? | |
pro-MMP-2 + H2O | - |
Rattus norvegicus | MMP-2 + MMP-2 propeptide | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | membrane type-I MMP, like the other five membrane type MMPs, differs from other MMPs in that it has a transmembrane domain that localizes the enzyme to the plasma membrane in addition to the three basic domains that characterize all other MMPs | Homo sapiens |
More | membrane type-I MMP, like the other five membrane type MMPs, differs from other MMPs in that it has a transmembrane domain that localizes the enzyme to the plasma membrane in addition to the three basic domains that characterize all other MMPs | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
membrane type-I matrix metalloproteinase | - |
Homo sapiens |
membrane type-I matrix metalloproteinase | - |
Rattus norvegicus |
membrane type-I MMP | - |
Homo sapiens |
membrane type-I MMP | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | cyclosporine A inhibits expression of membrane-type I MMP in gingiva | down |
Rattus norvegicus | cyclosporine A inhibits expression of membrane-type I MMP, but not of TIMP-2, in gingiva. Transcription of MMP-2 is unaffected, but translation is inhibited | down |