Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | membrane proteins are cleaved by MT1-MMP in a MMI270-sensitive manner | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
stable expression of FLAG-tagged MT1-MMP in A-431 cells, co-expression with Myc-tagged MT1-MMP | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E240A | a catalytically inactive MT1-MMP mutant | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | overview of MT1-MMP-associating proteins by localization and MT1-MMP-associating membrane proteins by function. Some proteins, such as MT1-SP, EGFR, 5T4, DCP, and CD36L1, preferentially precipitate pro-MT1-MMP, other proteins, e.g. GA733-1, HAI-1, HAI-2, TF, THBD, and CD9, precipitate preferentially the active form of MT1-MMP indicating that these proteins may form a complex on the cell surface | ? | - |
? | |
Type I collagen + H2O | Homo sapiens | cleavage of collagen by MT1-MMP regulates cell growth and invasion in a collagen-rich environment | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-431 cell | epithelial carcinoma cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | overview of MT1-MMP-associating proteins by localization and MT1-MMP-associating membrane proteins by function. Some proteins, such as MT1-SP, EGFR, 5T4, DCP, and CD36L1, preferentially precipitate pro-MT1-MMP, other proteins, e.g. GA733-1, HAI-1, HAI-2, TF, THBD, and CD9, precipitate preferentially the active form of MT1-MMP indicating that these proteins may form a complex on the cell surface | Homo sapiens | ? | - |
? | |
additional information | membrane proteins were cleaved by MT1-MMP in a MMI270-sensitive manner | Homo sapiens | ? | - |
? | |
Type I collagen + H2O | cleavage of collagen by MT1-MMP regulates cell growth and invasion in a collagen-rich environment | Homo sapiens | ? | - |
? | |
Type I collagen + H2O | type I collagen binds MT1-MMP via a hemopexin-like domain and is cleaved | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
membrane-type 1 matrix metalloproteinase 1 | - |
Homo sapiens |
MT1-MMP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | membrane-type 1 matrix metalloproteinase 1 is a potent modulator of the pericellular microenvironment and regulates cellular functions in physiological and pathological settings in mammals. MT1-MMP mediates its biological effects through cleavage of specific substrate proteins. Cleavage of collagen by MT1-MMP regulates cell growth and invasion in a collagen-rich environment | Homo sapiens |