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Literature summary for 3.4.24.80 extracted from

  • Niiya, D.; Egawa, N.; Sakamoto, T.; Kikkawa, Y.; Shinkawa, T.; Isobe, T.; Koshikawa, N.; Seiki, M.
    Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP): a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells (2009), J. Biol. Chem., 284, 27360-27369.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information membrane proteins are cleaved by MT1-MMP in a MMI270-sensitive manner Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
stable expression of FLAG-tagged MT1-MMP in A-431 cells, co-expression with Myc-tagged MT1-MMP Homo sapiens

Protein Variants

Protein Variants Comment Organism
E240A a catalytically inactive MT1-MMP mutant Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens overview of MT1-MMP-associating proteins by localization and MT1-MMP-associating membrane proteins by function. Some proteins, such as MT1-SP, EGFR, 5T4, DCP, and CD36L1, preferentially precipitate pro-MT1-MMP, other proteins, e.g. GA733-1, HAI-1, HAI-2, TF, THBD, and CD9, precipitate preferentially the active form of MT1-MMP indicating that these proteins may form a complex on the cell surface ?
-
?
Type I collagen + H2O Homo sapiens cleavage of collagen by MT1-MMP regulates cell growth and invasion in a collagen-rich environment ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell epithelial carcinoma cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information overview of MT1-MMP-associating proteins by localization and MT1-MMP-associating membrane proteins by function. Some proteins, such as MT1-SP, EGFR, 5T4, DCP, and CD36L1, preferentially precipitate pro-MT1-MMP, other proteins, e.g. GA733-1, HAI-1, HAI-2, TF, THBD, and CD9, precipitate preferentially the active form of MT1-MMP indicating that these proteins may form a complex on the cell surface Homo sapiens ?
-
?
additional information membrane proteins were cleaved by MT1-MMP in a MMI270-sensitive manner Homo sapiens ?
-
?
Type I collagen + H2O cleavage of collagen by MT1-MMP regulates cell growth and invasion in a collagen-rich environment Homo sapiens ?
-
?
Type I collagen + H2O type I collagen binds MT1-MMP via a hemopexin-like domain and is cleaved Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
membrane-type 1 matrix metalloproteinase 1
-
Homo sapiens
MT1-MMP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function membrane-type 1 matrix metalloproteinase 1 is a potent modulator of the pericellular microenvironment and regulates cellular functions in physiological and pathological settings in mammals. MT1-MMP mediates its biological effects through cleavage of specific substrate proteins. Cleavage of collagen by MT1-MMP regulates cell growth and invasion in a collagen-rich environment Homo sapiens