Literature summary for 3.4.24.80 extracted from

Devy, L.; Huang, L.; Naa, L.; Yanamandra, N.; Pieters, H.; Frans, N.; Chang, E.; Tao, Q.; Vanhove, M.; Lejeune, A.; van Gool, R.; Sexton, D.J.; Kuang, G.; Rank, D.; Hogan, S.; Pazmany, C.; Ma, Y.L.; Schoonbroodt, S.; Nixon, A.E.; Ladner, R.C.; Hoet, R.; Henderikx, P.; Tenhoor, C.; Rabbani, S.A.; Valentino, M.
Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis (2009), Cancer Res., 69, 1517-1526.

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Inhibitors

Inhibitors	Comment	Organism	Structure
DX-2400	represents a highly selective fully MMP-14 inhibitory antibody discovered using phage display technology. DX-2400 blocks proMMP-2 processing on tumor and endothelial cells, inhibits angiogenesis and slows tumor progression and formation of metastatic lesions in xenograft models	Homo sapiens
DX-2400	represents a highly selective fully MMP-14 inhibitory antibody discovered using phage display technology. DX-2400 blocks proMMP-2 processing on tumor and endothelial cells, inhibits angiogenesis and slows tumor progression and formation of metastatic lesions in xenograft models	Macaca fascicularis
DX-2400	represents a highly selective fully MMP-14 inhibitory antibody discovered using phage display technology. DX-2400 blocks proMMP-2 processing on tumor and endothelial cells, inhibits angiogenesis and slows tumor progression and formation of metastatic lesions in xenograft models	Mus musculus
DX-2400	represents a highly selective fully MMP-14 inhibitory antibody discovered using phage display technology. DX-2400 blocks proMMP-2 processing on tumor and endothelial cells, inhibits angiogenesis and slows tumor progression and formation of metastatic lesions in xenograft models	Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
57000	-	SDS-PAGE	Mus musculus
57000	-	SDS-PAGE	Rattus norvegicus
57000	-	SDS-PAGE	Macaca fascicularis
57000	-	SDS-PAGE, processed form of MMP-14	Homo sapiens
63000	-	SDS-PAGE, proMMP-14	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Macaca fascicularis	-	-	-
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	proMMP-14 detected at 63000 Da, processed form at 57000 Da using SDS-PAGE	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
B16-F1 cell	MMP-14 is weakly expressed in B16-F1 cells	Mus musculus	-
BT-474 cell	weakly expressed	Homo sapiens	-
HT-1080 cell	highly expressed	Homo sapiens	-
HUVEC cell	highly expressed	Homo sapiens	-
MDA-MB-231 cell	highly expressed	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-14	-	Mus musculus
MMP-14	-	Homo sapiens
MMP-14	-	Rattus norvegicus
MMP-14	-	Macaca fascicularis

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000002	-	DX-2400	-	Rattus norvegicus
0.0000003	-	DX-2400	-	Mus musculus
0.0000008	-	DX-2400	-	Homo sapiens
0.000004	-	DX-2400	-	Macaca fascicularis

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Release 2023.1 (January 2023)