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Literature summary for 3.4.24.80 extracted from

  • Itoh, Y.; Ito, N.; Nagase, H.; Evans, R.D.; Bird, S.A.; Seiki, M.
    Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP (2006), Mol. Biol. Cell, 17, 5390-5399.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)pLysS cells and COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
MT1F-DELTACat catalytic domain-deletion mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GM6001 0.1 mM Homo sapiens
hemopexin soluble hemopexin domain inhibits collagenolysis by preventing dimerization Homo sapiens
additional information not inhibited by TIMP-1 Homo sapiens
TIMP-2 0.0005 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Type I collagen + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
homodimer homodimerization of MT1-MMP through its hemopexin domain is essential for cleaving type I collagen fibers at the cell surface Homo sapiens

Synonyms

Synonyms Comment Organism
membrane-type 1 matrix metalloproteinase
-
 Homo sapiens
MMP-14
-
 Homo sapiens
MT1-MMP
-
 Homo sapiens