Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3)pLysS cells and COS-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
MT1F-DELTACat | catalytic domain-deletion mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GM6001 | 0.1 mM | Homo sapiens | |
hemopexin | soluble hemopexin domain inhibits collagenolysis by preventing dimerization | Homo sapiens | |
additional information | not inhibited by TIMP-1 | Homo sapiens | |
TIMP-2 | 0.0005 mM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Type I collagen + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | homodimerization of MT1-MMP through its hemopexin domain is essential for cleaving type I collagen fibers at the cell surface | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
membrane-type 1 matrix metalloproteinase | - |
Homo sapiens |
MMP-14 | - |
Homo sapiens |
MT1-MMP | - |
Homo sapiens |