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Literature summary for 3.4.24.80 extracted from
- Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in collage (2004), J. Biol. Chem., 279, 43336-43344.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | MMP-2 and MT1-MMP are cooperative dynamic components of a cell surface proteolytic axis involved in regulating the cellular signaling environment and pericellular collagen homeostasis | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | poor activity | Homo sapiens | ? | - |
? |  |
| type I collagen + H2O | bound by recombinant linker/hemopexin C domain of MT1-MMP | Homo sapiens | denatured type I collagen | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matrix metalloproteinase 14 | - |
Homo sapiens |
| membrane type MT1-MMP | - |
Homo sapiens |
| MT1-MMP | - |
Homo sapiens |
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