Activating Compound | Comment | Organism | Structure |
---|---|---|---|
furin | involved in the activation of MT1-MMP | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | MT1-MMP proteolysis of protective antigen markers makes the MT1-MMP-expressing aggressive invasive cells resistant to the cytotoxic effect of bipartite PA/FP59 toxin, synthetic inhibitors of MMPs are likely to increase the therapeutic anti-cancer effect of anthrax toxin, unique role of furin in the activation of protective antigen markers | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
catalytic domain of MT1-MMP expressed in Escherichia coli, MT1-MMP cDNAs cloned into vector pcDNA3-zeo | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E240A | catalytically inert | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AB815 | against hinge region of MT1-MMP | Homo sapiens | |
decanoyl-Arg-Val-Lys-Arg-chloromethylketone | furin inhibitor repressing activation of MMP-2 | Homo sapiens | |
GM6001 | fully blocks proteolysis of PA83 by MT1-MMP, inhibits MT1-MMP-dependent activation of proMMP-2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
39000 | - |
Western blot analysis, stable, catalytically inactive ectodomain form | Homo sapiens |
42000 | - |
Western blot analysis, stable, catalytically inactive ectodomain form | Homo sapiens |
60000 | - |
Western blot analysis | Homo sapiens |
63000 | - |
Western blot analysis, proenzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
purified from exclusion bodies | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-1080 cell | stably transfected with wild type MT1-MMP | Homo sapiens | - |
LoVo cell | furin-negative cells stably expressing wild type MT1-MMP and reconstituted furin-positive cells | Homo sapiens | - |
additional information | mock-transfected control cells | Homo sapiens | - |
U-251 cell | stably expresses wild type MT1-MMP | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
PA83 | efficiently cleaved by MT1-MMP at the substrate-enzyme ratio as low as 1: 50 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
membrane type-1 matrix metalloproteinase | - |
Homo sapiens |
MT1-MMP | - |
Homo sapiens |