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Literature summary for 3.4.24.80 extracted from

  • Will, H.; Atkinson, S.J.; Butler, G.S.; Smith, B.; Murphy, G.
    The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3 (1996), J. Biol. Chem., 271, 17119-17123.
    View publication on PubMed
Search for more literature for 3.4.24.80

Cloned(Commentary)

Cloned (Comment) Organism
catalytic domain Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibitor: TIMP-1 Homo sapiens
TIMP-2 rapid binding to catalytic site of enzyme Homo sapiens
TIMP-3 rapid binding to catalytic site of enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P50281
-
-

Purification (Commentary)

Purification (Comment) Organism
catalytic domain Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-GTQGQEARGS-dinitrophenol NH2 + H2O substrate covering the aggrecanase cleavage site of aggrecan Homo sapiens ?
-
 ?
(7-methoxycoumarin-4-yl)acetyl-LAQAVRSSK-dinitrophenol NH2 + H2O quenched fluorescent substrate mimicking the cleavage site of pro tumor necrosis factor alpha Homo sapiens ?
-
 ?
(7-methoxycoumarin-4-yl)acetyl-P-3-cyclohexylalanyl-norvalyl-HA-dinitrophenol NH2 + H2O collagenase substrate Homo sapiens ?
-
 ?
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-Ala-Arg-NH2 + H2O
-
 Homo sapiens ?
-
 ?
casein + H2O
-
 Homo sapiens ?
-
 ?
Gelatin + H2O
-
 Homo sapiens ?
-
 ?
progelatinase A + H2O cleaves at N37-L38 and N80-Y81 Homo sapiens ?
-
 ?
progelatinase A E375A + H2O syn: pro-matrix metalloproteinase 2, cleaves at N37-L38 only Homo sapiens ?
-
 ?