Any feedback?
Literature summary for 3.4.24.80 extracted from
- Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion (2003), Cancer Lett., 194, 1-11.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| claudin | activation of matrix metalloproteinase-2 is enhanced by association with claudin | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no inhibitor: TIMP-1 | Homo sapiens | |
| RECK | membrane anchor type proteinase inhibitor | Homo sapiens | |
| testican 3 | including its variant N-Tes | Homo sapiens | |
| TIMP-2 | - |
Homo sapiens | |
| TIMP-3 | tissue inhibitor of metalloproteinases | Homo sapiens | |
| TIMP-4 | tissue inhibitor of metalloproteinases | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Homo sapiens | 9986 | - |
| membrane | transmembrane protein | Homo sapiens | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
mature enzyme | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | healing process | ? | - |
? |  |
| additional information | Homo sapiens | involved in cell migration | ? | - |
? | |
| additional information | Homo sapiens | degrades components of tissue barriers, regulates cell-extracellular matrix interaction by processing cell adhesion molecules such as CD44 and integrin alpha v chain | ? | - |
? | |
| additional information | Homo sapiens | central role in tumor cell invasion | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P50281 | - |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone | - |
Mus musculus | - |
| brain cancer cell | - |
Homo sapiens | - |
| breast cancer cell | - |
Homo sapiens | - |
| cervical carcinoma cell | - |
Homo sapiens | - |
| colonic cancer cell | - |
Homo sapiens | - |
| embryo | - |
Mus musculus | - |
| fibroblast | - |
Mus musculus | - |
| fibroblast | - |
Homo sapiens | - |
| gastric cancer cell | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| additional information | stromal cell, adjacent to tumor cell nests | Homo sapiens | - |
| muscle | - |
Mus musculus | - |
| ovarian cancer cell | - |
Homo sapiens | - |
| thyroid gland | - |
Homo sapiens | - |
| urinary bladder cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| casein + H2O | - |
Homo sapiens | ? | - |
? | |
| CD44 + H2O | - |
Homo sapiens | ? | - |
? | |
| dermatan sulfate proteoglycan + H2O | - |
Homo sapiens | ? | - |
? | |
| Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
| Laminin-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| laminin-5 + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | healing process | Mus musculus | ? | - |
? | |
| additional information | involved in cell migration | Homo sapiens | ? | - |
? | |
| additional information | degrades components of tissue barriers, regulates cell-extracellular matrix interaction by processing cell adhesion molecules such as CD44 and integrin alpha v chain | Homo sapiens | ? | - |
? | |
| additional information | central role in tumor cell invasion | Homo sapiens | ? | - |
? | |
| pro-alpha v integrin + H2O | - |
Homo sapiens | ? | - |
? | |
| progelatinase A + H2O | syn: pro-matrix metalloproteinase 2, leads to activation of progelatinase A | Homo sapiens | ? | - |
? | |
| transglutaminase + H2O | tissue transglutaminase that binds fibronectin | Homo sapiens | ? | - |
? | |
| Type I collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| type II collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| type III collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| Vitronectin + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| multimer | homophilic oligomer formed through the homopexin-like domain | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
