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Literature summary for 3.4.24.73 extracted from

  • Klein, A.; Capitanio, J.S.; Maria, D.A.; Ruiz, I.R.
    Gene expression in SK-Mel-28 human melanoma cells treated with the snake venom jararhagin (2011), Toxicon, 57, 1-8.
    View publication on PubMed

Application

Application Comment Organism
medicine appropriate jararhagin concentration can have apoptotic and suppressant effects on SK-Mel-28 cells and can be used to develop potential anti-cancer drugs Bothrops jararaca

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
x * 52000, SDS-PAGE Bothrops jararaca

Organism

Organism UniProt Comment Textmining
Bothrops jararaca P30431
-
-

Purification (Commentary)

Purification (Comment) Organism
phenyl Superose column chromatography and Mono-Q column chromatography Bothrops jararaca

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Bothrops jararaca
-

Subunits

Subunits Comment Organism
? x * 52000, SDS-PAGE Bothrops jararaca

General Information

General Information Comment Organism
physiological function jararhagin 0.03 mg/ml upregulated genes TP53, CDKN1A, CDKN2A, CASP3, CASP5, CASP6, CASP8, and E-CDH in SKMel-28, and genes ITGB6, ITGB7, CASP3, TP53, and CDKN1B in mouse fibroblasts Bothrops jararaca