KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | quantitative analysis of the interaction of enzyme with Von Willebrand factor, VWF, A1 domains, overview | Bothrops jararaca |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Bothrops jararaca | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen XII + H2O | Bothrops jararaca | - |
? | - |
? | |
collagen XIV + H2O | Bothrops jararaca | - |
? | - |
? | |
matrilin 1 + H2O | Bothrops jararaca | - |
? | - |
? | |
matrilin 3 + H2O | Bothrops jararaca | - |
? | - |
? | |
matrilin 4 + H2O | Bothrops jararaca | - |
? | - |
? | |
additional information | Bothrops jararaca | the enzyme is a hemorrhagic P-III snake venom metalloproteinase | ? | - |
? | |
von Willebrand factor + H2O | Bothrops jararaca | Von Willebrand factor A1 domain interacts with the enzyme's cysteine-rich domain, which promotes site-specific proteolysis, jararhagin cleaves the substrate at sites adjacent to the A1 domain | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bothrops jararaca | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Bothrops jararaca | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen XII + H2O | - |
Bothrops jararaca | ? | - |
? | |
collagen XII + H2O | bovine substrate, the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains, cleavage pattern, overview | Bothrops jararaca | ? | - |
? | |
collagen XIV + H2O | - |
Bothrops jararaca | ? | - |
? | |
collagen XIV + H2O | bovine substrate, a fibril-associated collagen with interrupted triple helices, the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains, cleavage pattern, overview | Bothrops jararaca | ? | - |
? | |
matrilin 1 + H2O | - |
Bothrops jararaca | ? | - |
? | |
matrilin 1 + H2O | bovine substrate, the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains | Bothrops jararaca | ? | - |
? | |
matrilin 3 + H2O | - |
Bothrops jararaca | ? | - |
? | |
matrilin 3 + H2O | the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains, cleavage pattern, overview | Bothrops jararaca | ? | - |
? | |
matrilin 4 + H2O | - |
Bothrops jararaca | ? | - |
? | |
matrilin 4 + H2O | the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains | Bothrops jararaca | ? | - |
? | |
additional information | the enzyme is a hemorrhagic P-III snake venom metalloproteinase | Bothrops jararaca | ? | - |
? | |
additional information | the enzyme's disintegrin-like/cysteine-rich domains target it to to key extracellular matrix proteins or cell surface proteins, overview | Bothrops jararaca | ? | - |
? | |
von Willebrand factor + H2O | Von Willebrand factor A1 domain interacts with the enzyme's cysteine-rich domain, which promotes site-specific proteolysis, jararhagin cleaves the substrate at sites adjacent to the A1 domain | Bothrops jararaca | ? | - |
? | |
von Willebrand factor + H2O | Von Willebrand factor A1 domain interacts with the enzyme's cysteine-rich domain, which promotes site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains | Bothrops jararaca | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | snake venom metalloproteinases are members of the reprolysin family of metalloproteinases | Bothrops jararaca |