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Literature summary for 3.4.24.73 extracted from

  • Serrano, S.M.; Wang, D.; Shannon, J.D.; Pinto, A.F.; Polanowska-Grabowska, R.K.; Fox, J.W.
    Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation (2007), FEBS J., 274, 3611-3621.
    View publication on PubMed
Search for more literature for 3.4.24.73

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic evaluation of the interaction of the enzyme with immobilized Von Willebrand factor A1 domains, overview Bothrops jararaca

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Bothrops jararaca
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen XII + H2O Bothrops jararaca
-
 ?
-
 ?
collagen XIV + H2O Bothrops jararaca
-
 ?
-
 ?
matrilin 1 + H2O Bothrops jararaca
-
 ?
-
 ?
matrilin 3 + H2O Bothrops jararaca
-
 ?
-
 ?
matrilin 4 + H2O Bothrops jararaca
-
 ?
-
 ?
von Willebrand factor + H2O Bothrops jararaca binding between jararhagin cysteine-rich domain and Von Willebrand factor A1 domain leads to inhibition of Von Willebrand factor platelet aggregation activity, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bothrops jararaca
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Bothrops jararaca
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen XII + H2O
-
 Bothrops jararaca ?
-
 ?
collagen XII + H2O the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis Bothrops jararaca ?
-
 ?
collagen XIV + H2O
-
 Bothrops jararaca ?
-
 ?
collagen XIV + H2O the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis Bothrops jararaca ?
-
 ?
matrilin 1 + H2O
-
 Bothrops jararaca ?
-
 ?
matrilin 1 + H2O the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis Bothrops jararaca ?
-
 ?
matrilin 3 + H2O
-
 Bothrops jararaca ?
-
 ?
matrilin 3 + H2O the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis Bothrops jararaca ?
-
 ?
matrilin 4 + H2O
-
 Bothrops jararaca ?
-
 ?
matrilin 4 + H2O the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis Bothrops jararaca ?
-
 ?
von Willebrand factor + H2O binding between jararhagin cysteine-rich domain and Von Willebrand factor A1 domain leads to inhibition of Von Willebrand factor platelet aggregation activity, overview Bothrops jararaca ?
-
 ?
von Willebrand factor + H2O Von Willebrand factor A1 domain interacts with the enzyme's cysteine-rich domain, which promotes site-specific proteolysis, jararhagin cleaves the substrate at sites adjacent to the A1 domain Bothrops jararaca ?
-
 ?