Any feedback?
Literature summary for 3.4.24.72 extracted from
- Snake venom fibrin(ogen)olytic enzymes (2005), Toxicon, 45, 1021-1039.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | treatment of occlusive thrombi | Agkistrodon contortrix |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | complete and rapid inhibition | Agkistrodon contortrix |  |
| 1,10-phenanthroline | - |
Bothrops neuwiedi | |
| DTT | - |
Agkistrodon contortrix | |
| EDTA | - |
Agkistrodon contortrix | |
| EDTA | - |
Bothrops neuwiedi | |
| EDTA | - |
Gloydius halys | |
| o-phenanthroline | - |
Gloydius halys | |
| Tetraethylenepentamine | complete and rapid inhibition | Agkistrodon contortrix | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000000242 | - |
low molecular weight kininogen | - |
Agkistrodon contortrix | |
| 0.00000113 | - |
His-Thr-Glu-Phe-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.00000138 | - |
Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val | - |
Agkistrodon contortrix | |
| 0.00000164 | - |
His-Thr-Glu-Glu-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.00000247 | - |
His-Thr-Glu-Lys-Phe-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.00000338 | - |
His-Thr-Glu-Arg-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.00000391 | - |
His-Thr-Glu-Pro-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.00000415 | - |
His-Thr-Glu-His-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.00000528 | - |
His-Thr-Glu-Leu-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.00000579 | - |
His-Thr-Glu-Lys-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.00000739 | - |
His-Thr-Glu-Ala-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.00000832 | - |
His-Thr-Glu-Ser-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.00000937 | - |
His-Thr-Glu-Asn-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.0000654 | - |
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | - |
Agkistrodon contortrix | |
| 0.000579 | - |
His-Thr-Glu-Lys-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22520 | - |
calculated molecular weight | Bothrops neuwiedi |
| 22710 | - |
- |
Agkistrodon contortrix |
| 22710 | - |
calculated molecular weight | Gloydius halys |
| 23000 | - |
MALDI-TOF mass spectrometry | Agkistrodon contortrix |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agkistrodon contortrix | - |
subspecies Agkistrodon contortrix contortrix | - |
| Bothrops neuwiedi | - |
- |
- |
| Gloydius halys | - |
Agkistrodon halys brevicaudus | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| hydrophobic interaction high performance liquid chromatography, hydroxyapatite high performance liquid chromatography and cation exchange high performance liquid chromatography | Agkistrodon contortrix |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Gloydius halys | - |
| venom | - |
Bothrops neuwiedi | - |
| venom | - |
Agkistrodon contortrix | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O | - |
Agkistrodon contortrix | Arg-Pro-Pro-Gly-Phe-Ser-Pro + Phe-Arg | - |
ir | |
| Fibrin + H2O | - |
Gloydius halys | ? | - |
? | |
| Fibrin + H2O | - |
Bothrops neuwiedi | ? | - |
? | |
| Fibrin + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| Fibrinogen + H2O | - |
Gloydius halys | ? | - |
? | |
| Fibrinogen + H2O | - |
Bothrops neuwiedi | ? | - |
? | |
| Fibrinogen + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Ala-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Arg-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Asn-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Glu-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-His-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Leu-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Lys-Ala-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Lys-Arg-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Lys-Asn-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Lys-Glu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Lys-His-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Lys-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Lys-Phe-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Lys-Pro-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Lys-Ser-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Phe-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Pro-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| His-Thr-Glu-Ser-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| low molecular weight kininogen + H2O | - |
Agkistrodon contortrix | kallidin + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| brevilysin L6 | - |
Gloydius halys |
| neuwiedase | - |
Bothrops neuwiedi |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Bothrops neuwiedi |
| 37 | - |
- |
Agkistrodon contortrix |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | - |
Agkistrodon contortrix | |
| 0.0086 | - |
low molecular weight kininogen | - |
Agkistrodon contortrix | |
| 0.09 | - |
Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val | - |
Agkistrodon contortrix | |
| 0.16 | - |
His-Thr-Glu-Leu-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.2 | - |
His-Thr-Glu-Lys-Phe-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.45 | - |
His-Thr-Glu-Phe-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 0.46 | - |
His-Thr-Glu-Glu-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 1.59 | - |
His-Thr-Glu-Pro-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 1.97 | - |
His-Thr-Glu-Arg-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 2.23 | - |
His-Thr-Glu-Lys-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.98 | - |
His-Thr-Glu-Ser-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 5 | - |
His-Thr-Glu-Ala-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 5.19 | - |
His-Thr-Glu-His-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 6.03 | - |
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | - |
Agkistrodon contortrix | |
| 65.7 | - |
His-Thr-Glu-Asn-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.1 | 7.4 | - |
Agkistrodon contortrix |
| 7.4 | 8 | - |
Bothrops neuwiedi |
| 8.5 | 9.5 | - |
Gloydius halys |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Gloydius halys | - |
- |
4.8 |
| Bothrops neuwiedi | - |
- |
5.9 |
| Agkistrodon contortrix | - |
- |
6.8 |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
