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Literature summary for 3.4.24.72 extracted from

  • Bolger, M.B.; Swenson, S.; Markland, F.S., Jr.
    Three-dimensional structure of fibrolase, the fibrinolytic enzyme from southern copperhead venom, modeled from the X-ray structure of adamalysin II and atrolysin C (2001), AAPS Pharmsci., 3, E16.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine development of more effective therapeutic approaches for treating occlusive thrombotic diseases, potential clinical interest in fibrolase for pharmacologic dissolution of an established thrombus Agkistrodon contortrix contortrix

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains 1 mole of zinc per mole of protein Agkistrodon contortrix contortrix

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23000
-
-
Agkistrodon contortrix contortrix

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibrin + H2O Agkistrodon contortrix contortrix
-
?
-
?

Organism

Organism UniProt Comment Textmining
Agkistrodon contortrix contortrix P28891 southern copperhead snake
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibrin + H2O
-
Agkistrodon contortrix contortrix ?
-
?
additional information fibrolase identified in multiple isoforms Agkistrodon contortrix contortrix ?
-
?

pI Value

Organism Comment pI Value Maximum pI Value
Agkistrodon contortrix contortrix
-
-
6.8