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Literature summary for 3.4.24.7 extracted from

  • Weingarten, H.; Martin, R.; Feder, J.
    Synthetic substrates of vertebrate collagenase (1985), Biochemistry, 24, 6730-6734.
    View publication on PubMed
Search for more literature for 3.4.24.7

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0012
-
 acetyl-Pro-Leu-Gly-Leu-Leu-Gly-OC2H5
-
 Homo sapiens
0.0013
-
 acetyl-Pro-Leu-Gly-Ile-Leu-Gly-OC2H5
-
 Homo sapiens
0.0039
-
 acetyl-Pro-Leu-Gly-SCH[CH2CH(CH3)2CO]-Leu-Leu-OC2H5
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procollagenase is activated by trypsin Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast fibroblasts Homo sapiens
-
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Pro-Leu-Gly-Ile-Leu-Gly-OC2H5 + H2O
-
 Homo sapiens ?
-
 ?
acetyl-Pro-Leu-Gly-Leu-Ala-Gly-OC2H5 + H2O
-
 Homo sapiens ?
-
 ?
acetyl-Pro-Leu-Gly-Leu-Leu-Gly-OC2H5 + H2O
-
 Homo sapiens ?
-
 ?
acetyl-Pro-Leu-Gly-SCH[CH2CH(CH3)2CO]-Leu-Leu-OC2H5 + H2O
-
 Homo sapiens ?
-
 ?
acetyl-Pro-Leu-Gly-SCH[CH2CH(CH3)2]CO-Leu-Leu-OC2H5 + H2O
-
 Homo sapiens acetyl-Pro-Leu-Gly + HSCH[CH2CH(CH3)2]CO-Leu-Leu-OC2H5
-
 ?
Collagen + H2O
-
 Homo sapiens ?
-
 ?
additional information the enzyme prefers very lipophilic sequences Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.3
-
 acetyl-Pro-Leu-Gly-Ile-Leu-Gly-OC2H5
-
 Homo sapiens
5.83
-
 acetyl-Pro-Leu-Gly-Leu-Leu-Gly-OC2H5
-
 Homo sapiens
103
-
 acetyl-Pro-Leu-Gly-SCH[CH2CH(CH3)2CO]-Leu-Leu-OC2H5
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7.5
-
 Homo sapiens