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Literature summary for 3.4.24.7 extracted from

  • Nguyen, T.T.; Moon, Y.H.; Ryu, Y.B.; Kim, Y.M.; Nam, S.H.; Kim, M.S.; Kimura, A.; Kim, D.
    The influence of flavonoid compounds on the in vitro inhibition study of a human fibroblast collagenase catalytic domain expressed in E. coli (2013), Enzyme Microb. Technol., 52, 26-31.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
epigallocatechin gallate competitive. the galloyl group is important for inhibitory activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.026
-
 2,4-dinitrophenyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH pH 7.5, 25°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens P03956
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-dinitrophenyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH + H2O
-
 Homo sapiens ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0105
-
 epigallocatechin gallate pH 7.5, 25°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.014
-
 pH 7.5, 25°C Homo sapiens epigallocatechin gallate