Literature summary for 3.4.24.7 extracted from

Sun, X.; Wei, L.; Chen, Q.; Terek, R.
CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression (2010), Mol. Cancer, 9, 17.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chondrocyte	-	Homo sapiens	-
chondrosarcoma cell	cell line JJ, increased MMP1 expression in chondrosarcoma, mechanism, overview	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
mmp1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	increased MMP1 expression in JJ cell line can be inhibited by siRNA directed at HIF-1a or CXCR4, the CXCR4 inhibitor AMD3100, as well as with ERK inhibitor U0126 and ERK siRNA	down
Homo sapiens	hypoxia and specifically HIF-1a increase CXCR4, its ligand SDF1, and MMP1 expressions in JJ cell line and chondrosarcoma invasion in vitro, which can be inhibited by siRNA directed at HIF-1a or CXCR4, the CXCR4 inhibitor AMD3100, as well as with ERK inhibitor U0126 and ERK siRNA. Hypoxia increases MMP1 mRNA expression 9fold which is further increased to 23fold by SDF1 stimulation	up

General Information

General Information	Comment	Organism
malfunction	hypoxia and specifically HIF-1a increase CXCR4 and MMP1 expression in JJ cell line and chondrosarcoma invasion in vitro	Homo sapiens

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Release 2023.1 (January 2023)