Cloned (Comment) | Organism |
---|---|
quantitiative real-time PCR expression analysis of MMP-1 in brain regions in response to infection with Mycobacterium tuberculosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TIMP-1 | determination in cell culture medium | Homo sapiens | |
TIMP-2 | determination in cell culture medium | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | in the center of granulomas | Homo sapiens | - |
cell culture | - |
Homo sapiens | - |
central nervous system | - |
Homo sapiens | - |
microglia | - |
Homo sapiens | - |
monocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein + H2O | casein zymography assay method | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-1 | - |
Homo sapiens |
MMP-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | dexamethasone suppression of MMP-1 gene expression | down |
Homo sapiens | MMP-1 is 4.1fold induced by infection with Mycobacterium tuberculosis. Conditioned medium from Mycobacterium tuberculosis-infected human monocytes stimulates greater MMP-1 gene expression in human microglial cells than direct infection, overview. The induction is suppressed by dexamethasone. TNF-alpha and interleukin-1beta are necessary but not sufficient for upregulating MMP-1 secretion. NF-kappaB and AP-1 c-Jun/FosB heterodimers regulate induction of MMP-1 secretion by conditioned medium from Mycobacterium tuberculosis and are upregulated in granulomas from patients with cerebral tuberculosis. CoMTb upregulates MMP-1 gene expression and secretion in microglia | up |
General Information | Comment | Organism |
---|---|---|
malfunction | inflammatory tissue destruction is central to pathology in cerebral tuberculosis with microglial-derived matrix metalloproteinases playing a key role in driving such damage | Homo sapiens |