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Literature summary for 3.4.24.7 extracted from

  • Li, Y.; Samuvel, D.; Sundararaj, K.; Lopes-Virella, M.; Huang, Y.
    IL-6 and high glucose synergistically upregulate MMP-1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun (2010), J. Cell. Biochem., 110, 248-259.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.7

Cloned(Commentary)

Cloned (Comment) Organism
quantitative MMP-1 expression analysis, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
TIMP-1
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Type I collagen + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte primary Homo sapiens
-
U-937 cell mononuclear phagocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Type I collagen + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens curcumin, a potent inhibitor for AP-1, or simvastatin inhibit the expression of MMP-1. Suppression of c-Jun expression by RNA interference significantly inhibits MMP-1 expression down
Homo sapiens interleukin-6, high glucose, and lipopolysaccharide act in concert and synergistically upregulate MMP-1 expression by U-937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun, mechanism, overview. c-Jun is a key subunit of AP-1 known to be essential for MMP-1 transcription up

General Information

General Information Comment Organism
metabolism interleukin-6 and high glucose synergistically upregulate MMP-1 expression by U-937 cell mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun, MMP-1 regulation, overview Homo sapiens
additional information c-Jun is a key subunit of AP-1 known to be essential for MMP-1 transcription Homo sapiens
physiological function matrix metalloproteinases play a pivotal role in tissue remodeling and destruction in inflammation-associated diseases such as cardiovascular disease and periodontal disease Homo sapiens