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Literature summary for 3.4.24.7 extracted from
- Matrix metalloproteinase-1 expression induced by IL-1beta requires acid sphingomyelinase (2009), FEBS Lett., 583, 915-920.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | acid sphingomyelinase-deficient human fibroblasts fail to phosphorylate extracellular signal-regulated kinase, ERK, or upregulate MMP-1 mRNA and protein expression upon stimulation with interleukin-1 beta, overview. Transfection of acid sphingomyelinase restores MMP-1 production, while inhibition of acid sphingomyelinase with imipramine completely abrogates MMP-1 induction | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | required | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matrix metalloproteinase-1 | - |
Homo sapiens |
| MMP-1 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | matrix metalloproteinase-1 expression is induced by interleukin-1beta requiring acid sphingomyelinase, overview | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | MMP-1 is increased in inflammatory conditions leading to destruction of extracellular matrix | Homo sapiens |
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Release 2023.1 (January 2023)
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