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Literature summary for 3.4.24.7 extracted from

  • Genevay, S.; Finckh, A.; Mezin, F.; Tessitore, E.; Guerne, P.A.
    Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation (2009), Arthritis Res. Ther., 11, R169.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.7

Activating Compound

Activating Compound Comment Organism Structure
interleukin-1 receptor antagonist increases active MMP-1 level Homo sapiens
TNF increases active MMP-1 level Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dexamethasone significantly decreases active MMP-1 level and inhibits active MMP-1 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intervertebral disc
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 basal activity in different subjects, overview Homo sapiens

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-1
-
 Homo sapiens
MMP-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens dexamethasone, and less potent also interleukin-1Ra and TNF, decrease levels of pro-MMP-1 down

General Information

General Information Comment Organism
physiological function MMP-1 is involved in spontaneous resorption of disc herniation after sciatica, overview. MMP-3 appears to play a greater role than MMP-1 in disc herniation resorption Homo sapiens