Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | rapamycin-induced MMP-1 gene transactivation and AP-1/DNA interactions, rapamycin significantly enhances the expression of interstitial collagenase at the protein and mRNA levels and transcriptionally, rapamycin efficiently activates activator protein-1, AP-1-driven transcription by rapidly inducing c-jun/AP-1 phosphorylation with activation of the c-Jun N-terminal kinase cascade, resulting in enhanced binding of AP-1-DNA complex formation and AP-1-dependent gene transactivation, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
integrity of MMP-1 promoter AP-1 binding site is necessary for transactivation by rapamycin, regulation, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the JNK inhibitor SP600125 inhibits rapamycin-induced MMP-1 gene transactivation and AP-1/DNA interactions, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | Homo sapiens | degradation | ? | - |
? | |
additional information | Homo sapiens | enzyme regulation on expression and protein levels, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | from lung | Homo sapiens | - |
WI-26 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | degradation | Homo sapiens | ? | - |
? | |
additional information | enzyme regulation on expression and protein levels, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-1 | - |
Homo sapiens |