Any feedback?
Literature summary for 3.4.24.7 extracted from
- Substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast (2007), Exp. Lung Res., 33, 151-167.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| tissue inhibitor of matrix metalloproteinase-1 | is not influenced by substance P | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen I + H2O | Homo sapiens | degradation | ? | - |
? | |
| additional information | Homo sapiens | substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | primary lung fibroblast cell lines | Homo sapiens | - |
| lung | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity in primary lung fibroblast cell lines in presence or absence of substance P, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen I + H2O | degradation | Homo sapiens | ? | - |
? | |
| additional information | substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matrix metalloproteinase-1 | - |
Homo sapiens |
| MMP-1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
