Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Trypsin | procollagenase activated to collagenase | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ClCH2CO-(N-OH)Leu-Ala-Gly-NH2 | 2-5 mM, 25°C, pH 7.4, Tris buffer, strong irreversible inhibition, inhibition increases with higher temperatures and inhibitor concentration | Homo sapiens | |
ClCH2CO-(N-OH)Phe-Ala-Ala-NH2 | - |
Homo sapiens | |
phthaloyl-Gly(P)-Ile-Trp-NHBzl | 50 µM, 25°C, pH 7.4, Tris buffer, reversible inhibition, protects the enzyme partially from inactivation by ClCH2CO-(N-OH)Leu-Ala-Gly-NH2 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53000 | - |
calculated | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | procollagenase activated by treatment with trypsin | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | gingival | Homo sapiens | - |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 7 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.5 | - |
ClCH2CO-(N-OH)Leu-Ala-Gly-NH2 | 25°C, pH 7.4, Tris buffer | Homo sapiens | |
2.5 | - |
ClCH2CO-(N-OH)Phe-Ala-Ala-NH2 | 25°C, pH 7.4, Tris buffer | Homo sapiens |