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Literature summary for 3.4.24.68 extracted from

  • Surana, S.; Tosolini, A.P.; Meyer, I.F.G.; Fellows, A.D.; Novoselov, S.S.; Schiavo, G.
    The travel diaries of tetanus and botulinum neurotoxins (2018), Toxicon, 147, 58-67 .
    View publication on PubMed
Search for more literature for 3.4.24.68

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
vesicle associated membrane protein + H2O Clostridium tetani
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium tetani
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vesicle associated membrane protein + H2O
-
 Clostridium tetani ?
-
 ?

Synonyms

Synonyms Comment Organism
TeNT
-
 Clostridium tetani
Tetanus neurotoxin
-
 Clostridium tetani

General Information

General Information Comment Organism
physiological function the enzyme undergoes binding to specific components of the basal membrane at the neuromuscular junction, is endocytosed into motor neurons and sorted to axonal signaling endosomes. Following this, the enzyme is transported to the soma of motor neurons located in the spinal cord or brainstem, and then transcytosed to inhibitory interneurons, where it blocks synaptic transmission. Enzyme-induced impairment of inhibitory input leads to hyperactivity of motor neurons, causing spastic paralysis Clostridium tetani