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Literature summary for 3.4.24.68 extracted from

  • Ghotloo, S.; Golsaz-Shirazi, F.; Amiri, M.M.; Jeddi-Tehrani, M.; Shokri, F.
    Epitope mapping of tetanus toxin by monoclonal antibodies implication for immunotherapy and vaccine design (2019), Neurotox. Res., 37, 239-249 .
    View publication on PubMed
Search for more literature for 3.4.24.68

Application

Application Comment Organism
medicine monoclonal antibody MAb 5C4 is the only anti-fragment C (heavy chain) antibody which is capable of blocking the binding of recombinant fragment C to GT1b gangliosides Clostridium tetani

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Clostridium tetani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
vesicle associated membrane protein-2 + H2O Clostridium tetani
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium tetani
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vesicle associated membrane protein-2 + H2O
-
 Clostridium tetani ?
-
 ?

Synonyms

Synonyms Comment Organism
TeNT
-
 Clostridium tetani
Tetanus neurotoxin
-
 Clostridium tetani
tetanus toxin
-
 Clostridium tetani

General Information

General Information Comment Organism
metabolism the enzyme cleaves a neuronal soluble N-ethylmaleimide-sensitive attachment receptor protein, leading to the blockade of inhibitory neurotransmitter release and subsequent generalized muscular spasm Clostridium tetani