Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.65 extracted from

  • Kaspiris, A.; Khaldi, L.; Chronopoulos, E.; Vasiliadis, E.; Grivas, T.B.; Kouvaras, I.; Dagkas, S.; Papadimitriou, E.
    Macrophage-specific metalloelastase (MMP-12) immunoexpression in the osteochondral unit in osteoarthritis correlates with BMI and disease severity (2015), Pathophysiology, 22, 143-151 .
    View publication on PubMed
Search for more literature for 3.4.24.65

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone subchondral Homo sapiens
-
bone lining cell
-
 Homo sapiens
-
cartilage
-
 Homo sapiens
-
chondrocyte metalloproteinase 12 (MMP-12) is induced in chondrocytes during fetal development and malignant transformation Homo sapiens
-
macrophage
-
 Homo sapiens
-
additional information enzyme expression analysis in bones and cartilage of healthy subjects and patients with osteoarthritis (OA), overview. During disease progression, MMP-12 is expressed at the sides of the cartilage and bone erosion and in the bone cysts. Furthermore, it is traced in the osteocytes of the subchondral bone. Osteoblast-like cells and bone lining cells express MMP-12 during the stage of severe OA. MMP-12 expression is positively correlated with the age and the BMI of OA patients Homo sapiens
-
osteoblast
-
 Homo sapiens
-
osteoclast
-
 Homo sapiens
-
osteocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
macrophage-specific metalloelastase
-
 Homo sapiens
MMP-12
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens metalloproteinase 12 (MMP-12) is induced in chondrocytes during fetal development and malignant transformation up