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Literature summary for 3.4.24.65 extracted from

  • Wagner, C.J.; Schultz, C.; Mall, M.A.
    Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease (2016), Mol. Cell. Pediatr., 3, 25 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.65

Application

Application Comment Organism
medicine the enzyme is a potential target in treatment of cystic fibrosis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information gene ration of enzyme-deficient mutant betaENaC-overexpressing mice, betaENaC-Tg/MMP12-/- mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Mus musculus
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-

Organism

Organism UniProt Comment Textmining
Mus musculus P34960
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
macrophage metalloelastase
-
 Mus musculus
matrix metalloproteinase 12
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 Mus musculus
MMP12
-
 Mus musculus

General Information

General Information Comment Organism
metabolism neutrophil elastase (NE) and matrix metalloproteinase 12 (MMP12) activity is increased at the surface of bronchoalveolar neutrophils and macrophages and is associated with structural lung damage in betaENaC-Tg mice Mus musculus
physiological function macrophage elastase (matrix metalloproteinase 12, MMP12) is an additional protease contributing to early lung damage in betaENaC-overexpressing (betaENaC-Tg) mice, suffering cystic fibrosis (CF)-like lung disease, besides neutrophil elastatse (EC 3.4.21.37). MMP12 contributes to structural lung damage in mice with CF-like lung disease Mus musculus