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Literature summary for 3.4.24.65 extracted from
- Macrophage elastase suppresses white adipose tissue expansion with cigarette smoking (2014), Am. J. Respir. Cell Mol. Biol., 51, 822-829.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | chronic cigarette smoke exposure leads to macrophage accumulation and restores adipose MMP12 activity, thereby suppressing adipose tissue mass and vascularity | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P34960 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MMP-12 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | MMP12 content and activity are increased in the adipose tissue of wild-type mice at 2 weeks of age, leading to elevated endostatin production, inhibition of vascular endothelial growth factor secretion, and decreased adipose tissue vascularity. By 8 weeks of age, adipose MMP12 levels subside, and the protein is no longer detectable | Mus musculus |
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Release 2023.1 (January 2023)
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