Any feedback?
Literature summary for 3.4.24.65 extracted from
- Macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases (2009), Expert Opin. Ther. Targets, 13, 287-295.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | MMP-12 plays a predominant role in the inflammatory process induced by cigarette smoke, and therefore is potentially an important therapeutic target for the treatment of chronic obstructive pulmonary diseases | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | development of pulmonary fibrosis in MMP-12 -/- knockout mice | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| TIMP-1 | a major fibrogenic effector in lungs. Indeed, upon fibrogenic stimuli, large amounts of TIMP-1 in the remodeling tissue are believed to contribute to the creation of a non-degrading environment, leading to the alteration of protease-anti-protease balance, extracellular matrix accumulation, and tissue fibrosis. MMP-12 deficiency does not seem to be involved in TIMP-1 regulation | Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22000 | - |
x * 54000, pro-MMP-12, x * 22000, active mature MMP-12 | Homo sapiens |
| 54000 | - |
x * 54000, pro-MMP-12, x * 22000, active mature MMP-12 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Elastin + H2O | Mus musculus | - |
? | - |
? |  |
| Elastin + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
Balb/c and C57BL/6 mice | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | pro-MMP-12 is activated to mature MMP-12 | Mus musculus |
| proteolytic modification | pro-MMP-12 is activated to mature MMP-12 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelial cell | bronchial | Homo sapiens | - |
| lung | - |
Mus musculus | - |
| lung | - |
Homo sapiens | - |
| macrophage | alveolar | Homo sapiens | - |
| smooth muscle cell | airway | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha1-antitrypsin + H2O | - |
Mus musculus | ? | - |
? | |
| alpha1-antitrypsin + H2O | - |
Homo sapiens | ? | - |
? | |
| Elastin + H2O | - |
Mus musculus | ? | - |
? | |
| Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibronectin + H2O | - |
Mus musculus | ? | - |
? | |
| Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
| Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
| Laminin + H2O | - |
Mus musculus | ? | - |
? | |
| Laminin + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | MMP-12 has in vitro, a wide variety of potential substrates, including type IV collagen, fibronectin, laminin, and gelatin, as well as non-matrix proteins such as alpha1-antitrypsin and latent TNF-alpha | Mus musculus | ? | - |
? | |
| additional information | MMP-12 has in vitro, a wide variety of potential substrates, including type IV collagen, fibronectin, laminin, and gelatin, as well as non-matrix proteins such as alpha1-antitrypsin and latent TNF-alpha | Homo sapiens | ? | - |
? | |
| TNF-alpha + H2O | - |
Mus musculus | ? | - |
? | |
| TNF-alpha + H2O | - |
Homo sapiens | ? | - |
? | |
| Type IV collagen + H2O | - |
Mus musculus | ? | - |
? | |
| Type IV collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 54000, pro-MMP-12, x * 22000, active mature MMP-12 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| macrophage metalloelastase | - |
Mus musculus |
| macrophage metalloelastase | - |
Homo sapiens |
| MMP-12 | - |
Mus musculus |
| MMP-12 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | MMP-12 expression is upregulated by other matrix components such as hyaluronan fragments, cytokines, and growth factors, for example by TGF-beta, IFN-gamma and EGF, and serine proteases such as thrombin and plasmin | up |
| Homo sapiens | MMP-12 expression is upregulated by other matrix components such as hyaluronan fragments, cytokines, and growth factors, for example by TGF-beta, IFN-gamma and EGF, and serine proteases such as thrombin and plasmin | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | macrophage elastase is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling in inflammatory respiratory diseases such as chronic obstructive pulmonary diseases, including emphysema. MMP-12 is also involved in asthma and fibrosis. Inhibitors demonstrate a reduction in both the inflammatory process and airspace enlargement in lung tissue. MMP-12 plays a predominant role in the inflammatory process induced by cigarette smoke | Homo sapiens |
| physiological function | macrophage elastase is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling in inflammatory respiratory diseases such as chronic obstructive pulmonary diseases, including emphysema. MMP-12 is involved in fibrosis, mechanism, overview. Balb/c mice are resistant to the development of pulmonary fibrosis, while C57BL/6 mice are not, overview | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
