Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.65 extracted from

  • Nenan, S.; Lagente, V.; Planquois, J.M.; Hitier, S.; Berna, P.; Bertrand, C.P.; Boichot, E.
    Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat (2007), Eur. J. Pharmacol., 559, 75-81.
    View publication on PubMed

Application

Application Comment Organism
analysis the enzyme can be utilized for pharmacological evaluation of anti-inflammatory mechanisms of action Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dexamethasone in vivo inhibition of the human enzyme in mice leading to inhibited cytokine release and neutrophil influx, overview Homo sapiens
marimastat in vivo inhibition of the human enzyme in mice leading to inhibited macrophage recruitment, neutrophil influx, and cytokine release, overview Homo sapiens
rolipram in vivo inhibition of the human enzyme in mice leading to inhibited neutrophil influx, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme induces inflammation in murine airways after direct instillation eliciting the inflammatory response by neutrophil influx, cytokine release, and gelatinase activation, and delayed response by macrophage recruitment, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme induces inflammation in murine airways after direct instillation eliciting the inflammatory response by neutrophil influx, cytokine release, and gelatinase activation, and delayed response by macrophage recruitment, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Metalloelastase
-
Homo sapiens
MMP-12
-
Homo sapiens