Literature summary for 3.4.24.65 extracted from

Liu, M.; Sun, H.; Wang, X.; Koike, T.; Mishima, H.; Ikeda, K.; Watanabe, T.; Ochiai, N.; Fan, J.
Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis (2004), Arthritis Rheum., 50, 3112-3117.

Search for more literature for 3.4.24.65

Application

Application	Comment	Organism
medicine	inhibition of MMP-12 may be a potential modality for the treatment of rheumatoid arthritis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	inhibition of MMP-12 may be a potential modality for the treatment of rheumatoid arthritis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
synovial tissue	mainly expressed by inflammatory macrophages in the rhematoid arthritis synovial membrane. Rheumatoid synovial tissue contains higher levels of MMP-12 messenger RNA than does osteoarthritis synovial tissue. Macrophage-derived MMP-12 may play an important role in the destructive process in rheumatoid arthritis	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
matrix metalloproteinase 12	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)