Literature summary for 3.4.24.65 extracted from

Lang, R.; Kocourek, A.; Braun, M.; Tschesche, H.; Huber, R.; Bode, W.; Maskos, K.
Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure (2001), J. Mol. Biol., 312, 731-742.

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Cloned(Commentary)

Cloned (Comment)	Organism
MMP-12 catalytic domain, cd(EA)MMP-12 overexpressed in Escherichia coli strain BL21 (DE3)	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting drop vapor diffusion technique, crystallized in complex with inhibitor batimastat, BB-94, monoclinic space group C2, crystal cell constants a : 51.91 A, b : 60.26 A, c : 54.61 A	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
batimastat	BB-94	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	able to degrade all components of extracellular matrix	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P45452	human	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	able to degrade all components of extracellular matrix	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
Metalloelastase	-	Homo sapiens
MMP-12	-	Homo sapiens

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Release 2023.1 (January 2023)