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Literature summary for 3.4.24.65 extracted from

  • Gronski, T.J., Jr.; Martin, R.L.; Kobayashi, D.K.; Walsh, B.C.; Holman, M.C.; Huber, M.; Van Wart, H.E.; Shapiro, S.D.
    Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase (1997), J. Biol. Chem., 272, 12189-12194.
    View publication on PubMed

Application

Application Comment Organism
medicine abnormal expression of HME may contribute to destructive processes such as pulmonary empysema and vascular aneurysm formation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cloned and expressed in Escherichia coli BL21(DE3) Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
extracellular matrix protein + H2O Homo sapiens may be required for macrophages to penetrate basement membranes and remodel injured tissue during inflammation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
specific activity 265 cpm/microgram Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Ala-Trp-Arg-Ser-NH2 + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Arg-Trp-Arg-Ser-NH2 + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Glu-Trp-Arg-Ser-NH2 + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-NH2 + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Lys-Trp-Arg-Ser-NH2 + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Phe-Trp-Arg-Ser-NH2 + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Ser-Trp-Arg-Ser-NH2 + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Trp-Trp-Arg-Ser-NH2 + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Tyr-Trp-Arg-Ser-NH2 + H2O
-
Homo sapiens ?
-
?
alpha-1-antitrypsin + H2O recombinant enzyme rHME Homo sapiens ?
-
?
chondroitan sulfate + H2O recombinant enzyme rHME Homo sapiens ?
-
?
Elastin + H2O
-
Homo sapiens ?
-
?
enactin + H2O recombinant enzyme rHME Homo sapiens ?
-
?
extracellular matrix protein + H2O may be required for macrophages to penetrate basement membranes and remodel injured tissue during inflammation Homo sapiens ?
-
?
Fibronectin + H2O recombinant enzyme rHME Homo sapiens ?
-
?
heparan sulfate + H2O recombinant enzyme rHME Homo sapiens ?
-
?
Laminin + H2O recombinant enzyme rHME Homo sapiens ?
-
?
Type IV collagen + H2O recombinant enzyme rHME Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
HME
-
Homo sapiens
ME
-
Homo sapiens
MMP-12
-
Homo sapiens
rHME
-
Homo sapiens