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Literature summary for 3.4.24.62 extracted from
- Magnolysin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 1039-1042.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-Arg12 derivate of pro-oxytocin/neurophysin (1-20) | - |
Bos taurus | |
| D-Arg12 derivate of pro-oxytocin/neurophysin (1-20) | - |
Homo sapiens | |
| EDTA | inhibits at millimolar concentrations | Bos taurus |  |
| EDTA | inhibits at millimolar concentrations | Homo sapiens | |
| EGTA | inhibits at millimolar concentrations | Bos taurus | |
| EGTA | inhibits at millimolar concentrations | Homo sapiens | |
| additional information | not inhibited by PMSF, apronitin or pepstatin | Bos taurus | |
| additional information | not inhibited by PMSF, apronitin or pepstatin | Homo sapiens | |
| p-(chloromercuri)-benzenesulfonic acid | partially sensitive to | Bos taurus | |
| p-(chloromercuri)-benzenesulfonic acid | partially sensitive to | Homo sapiens | |
| PCMB | partially sensitive to | Bos taurus | |
| PCMB | partially sensitive to | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | 65000 | - |
Homo sapiens |
| 55000 | 65000 | - |
Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| affinity chromatography | Homo sapiens |
| affinity chromatography | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| corpus luteum | - |
Bos taurus | - |
| additional information | secretory granule from neurohypophysis hypothalamus | Bos taurus | - |
| ovary | - |
Homo sapiens | - |
| ovary | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | peptides bearing Nle or D-Arg at subsite P1 or containing Nle or D-Lys at subsite P2 remain uncleaved, substrate bearing the Lys-Arg doublet is hydrolyzed with best efficiency, a minimal length of eight residues is necessary to allow for substrate binding | Homo sapiens | ? | - |
? | |
| additional information | peptides bearing Nle or D-Arg at subsite P1 or containing Nle or D-Lys at subsite P2 remain uncleaved, substrate bearing the Lys-Arg doublet is hydrolyzed with best efficiency, a minimal length of eight residues is necessary to allow for substrate binding | Bos taurus | ? | - |
? | |
| Pro-oxytocin/neurophysin + H2O | primary cleavage at the Arg12-Ala13 bond | Homo sapiens | ? | - |
? | |
| Pro-oxytocin/neurophysin + H2O | primary cleavage at the Arg12-Ala13 bond | Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Homo sapiens |
| monomer | - |
Bos taurus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| pro-ocytocin convertase | - |
Homo sapiens |
| pro-ocytocin convertase | - |
Bos taurus |
| pro-ocytocin/neurophysin-converting enzyme | - |
Homo sapiens |
| pro-ocytocin/neurophysin-converting enzyme | - |
Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Homo sapiens |
| 7 | - |
- |
Bos taurus |
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