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Literature summary for 3.4.24.61 extracted from

  • Ohno, M.; Hiraoka, Y.; Lichtenthaler, S.; Nishi, K.; Saijo, S.; Matsuoka, T.; Tomimoto, H.; Araki, W.; Takahashi, R.; Kita, T.; Kimura, T.; Nishi, E.
    Nardilysin prevents amyloid plaque formation by enhancing alpha-secretase activity in an Alzheimers disease mouse model (2014), Neurobiol. Aging, 35, 213-222.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Mus musculus the enzyme enhances alpha-cleavage of amyloid precursor protein, which results in the decreased generation of amyloid beta in vitro ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BHG1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O the enzyme enhances alpha-cleavage of amyloid precursor protein, which results in the decreased generation of amyloid beta in vitro Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
N-Arginine dibasic convertase
-
 Mus musculus
NRDc
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the activity of alpha-secretase in the mouse brain is enhanced by the overexpression of the enzyme. The enzyme controls amyloid beta formation through the regulation of alpha-secretase Mus musculus