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Literature summary for 3.4.24.61 extracted from

  • Hiraoka, Y.; Matsuoka, T.; Ohno, M.; Nakamura, K.; Saijo, S.; Matsumura, S.; Nishi, K.; Sakamoto, J.; Chen, P.; Inoue, K.; Fushiki, T.; Kita, T.; Kimura, T.; Nishi, E.
    Critical roles of nardilysin in the maintenance of body temperature homoeostasis (2014), Nat. Commun., 5, 3224.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.61

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc peptidase Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
PGC-1alpha + H2O Mus musculus nardilysin and PGC-1alpha interact and colocalize at the uncoupling protein 1 enhancer, where the enzyme represses PGC-1alpha activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BHG1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
PGC-1alpha + H2O nardilysin and PGC-1alpha interact and colocalize at the uncoupling protein 1 enhancer, where the enzyme represses PGC-1alpha activity Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
N-Arginine dibasic convertase
-
 Mus musculus
NRDc
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme-deficient mice show increased energy expenditure owing to enhanced brown adipose tissue thermogenesis and hyperactivity as well as hypothermia and cold intolerance Mus musculus
physiological function the enzyme is a critical regulator of body temperature homoeostasis Mus musculus