BRENDA - Enzyme Database
show all sequences of 3.4.24.61

Nardilysin in human brain diseases: both friend and foe

Bernstein, H.; Stricker, R.; Dobrowolny, H.; Steiner, J.; Bogerts, B.; Trbner, K.; Reiser, G.; Amino Acids 45, 269-278 (2013)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
the enzyme plays a role in the pathophysiology of schizophrenia
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
alpha-neoendorphin + H2O
Homo sapiens
-
?
-
-
?
dynorphin A + H2O
Homo sapiens
-
?
-
-
?
Glucagon + H2O
Homo sapiens
-
?
-
-
?
malate dehydrogenase + H2O
Homo sapiens
-
?
-
-
?
somatostatin-28 + H2O
Homo sapiens
-
?
-
-
?
tumor necrosis factor-alpha + H2O
Homo sapiens
-
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
O43847
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
alpha-neoendorphin + H2O
-
733071
Homo sapiens
?
-
-
-
?
dynorphin A + H2O
-
733071
Homo sapiens
?
-
-
-
?
Glucagon + H2O
-
733071
Homo sapiens
?
-
-
-
?
malate dehydrogenase + H2O
-
733071
Homo sapiens
?
-
-
-
?
somatostatin-28 + H2O
-
733071
Homo sapiens
?
-
-
-
?
tumor necrosis factor-alpha + H2O
-
733071
Homo sapiens
?
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
N-Arginine dibasic convertase
-
Homo sapiens
NRDc
-
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
medicine
the enzyme plays a role in the pathophysiology of schizophrenia
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
alpha-neoendorphin + H2O
Homo sapiens
-
?
-
-
?
dynorphin A + H2O
Homo sapiens
-
?
-
-
?
Glucagon + H2O
Homo sapiens
-
?
-
-
?
malate dehydrogenase + H2O
Homo sapiens
-
?
-
-
?
somatostatin-28 + H2O
Homo sapiens
-
?
-
-
?
tumor necrosis factor-alpha + H2O
Homo sapiens
-
?
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
alpha-neoendorphin + H2O
-
733071
Homo sapiens
?
-
-
-
?
dynorphin A + H2O
-
733071
Homo sapiens
?
-
-
-
?
Glucagon + H2O
-
733071
Homo sapiens
?
-
-
-
?
malate dehydrogenase + H2O
-
733071
Homo sapiens
?
-
-
-
?
somatostatin-28 + H2O
-
733071
Homo sapiens
?
-
-
-
?
tumor necrosis factor-alpha + H2O
-
733071
Homo sapiens
?
-
-
-
?
Expression
Organism
Commentary
Expression
Homo sapiens
there is strongly decreased neuronal enzyme expression in Down syndrome. The enzyme is down-regulated (about 1.21fold) in brains of individuals with bipolar disorder
down
Homo sapiens
the enzyme is highly expressed in neuroblastoma cells
up
General Information
General Information
Commentary
Organism
physiological function
the interaction between the enzyme and centaurin-1alpha contribute to brain structural damage observed in Alzheimer's disease
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
physiological function
the interaction between the enzyme and centaurin-1alpha contribute to brain structural damage observed in Alzheimer's disease
Homo sapiens
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
there is strongly decreased neuronal enzyme expression in Down syndrome. The enzyme is down-regulated (about 1.21fold) in brains of individuals with bipolar disorder
down
Homo sapiens
the enzyme is highly expressed in neuroblastoma cells
up
Other publictions for EC 3.4.24.61
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
753298
Yoh
Serum nardilysin, a surrogate ...
Homo sapiens
Clin. Cancer Res.
25
619-628
2019
-
1
-
-
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-
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2
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-
-
-
753303
Chen
Clinical determination of ser ...
Homo sapiens
Clin. Chim. Acta
494
8-13
2019
-
1
-
-
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4
-
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1
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1
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753760
Ikuta
Nardilysin inhibits pancreati ...
Mus musculus
Gut
68
882-892
2019
-
-
-
-
-
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-
-
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4
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1
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1
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-
-
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-
-
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-
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-
2
2
-
-
-
754562
Kanda
Nardilysin controls intestina ...
Homo sapiens, Mus musculus
JCI Insight
3
91316
2018
-
-
-
-
-
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-
-
-
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4
-
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1
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4
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1
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-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
755470
Kimura
Nardilysin regulates inflamma ...
Mus musculus
Sci. Rep.
7
43052
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
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-
2
-
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2
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
752627
Segretain
Ultrastructural localization ...
Mus musculus
Basic Clin. Androl.
26
5
2016
-
-
-
-
-
-
-
-
2
1
-
-
-
6
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
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-
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-
2
1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
753390
Nishi
Nardilysin is required for ma ...
Mus musculus
Diabetes
65
3015-3027
2016
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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-
-
-
-
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2
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-
-
-
-
-
-
-
2
2
-
-
-
734761
Hiraoka
Critical roles of nardilysin i ...
Mus musculus
Nat. Commun.
5
3224
2014
-
-
-
-
-
-
-
-
-
1
-
1
-
7
-
-
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1
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2
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
734781
Ohno
Nardilysin prevents amyloid pl ...
Mus musculus
Neurobiol. Aging
35
213-222
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
6
-
-
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-
-
3
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1
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2
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1
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-
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3
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
733071
Bernstein
Nardilysin in human brain dise ...
Homo sapiens
Amino Acids
45
269-278
2013
-
1
-
-
-
-
-
-
-
-
-
6
-
4
-
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-
-
-
3
-
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6
-
2
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1
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-
6
-
-
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-
-
3
-
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6
-
-
-
-
-
-
-
-
-
2
1
1
2
-
-
720003
Li
Identification and Characteria ...
Homo sapiens
J. Biol. Chem.
287
10089-10098
2012
-
-
1
-
5
-
-
-
2
-
-
2
-
1
-
-
1
-
-
-
-
-
2
-
2
-
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-
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1
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5
-
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2
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2
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1
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2
-
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-
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-
-
-
-
-
1
1
-
-
-
733727
Kanda
Nardilysin and ADAM proteases ...
Homo sapiens
EMBO Mol. Med.
4
396-411
2012
-
-
-
-
-
-
-
-
1
1
-
1
-
3
-
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1
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1
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2
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1
1
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1
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1
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1
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-
-
-
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1
2
2
1
-
-
718147
Kessler
Antigen processing by nardilys ...
Homo sapiens
Nat. Immunol.
12
45-53
2011
-
-
-
-
-
-
-
-
-
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4
-
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2
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1
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2
-
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-
-
-
-
-
-
-
-
1
1
-
-
-
719245
Borrmann
Tubulin potentiates the intera ...
Homo sapiens
Cell Tissue Res.
346
89-98
2011
-
-
1
-
2
-
-
-
2
-
-
1
-
1
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1
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1
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1
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1
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1
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1
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1
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1
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720552
Borrmann
Retinoic acid-induced upregula ...
Homo sapiens
Neurochem. Int.
59
936-944
2011
1
-
-
-
-
-
-
-
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1
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1
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1
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1
1
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1
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1
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1
-
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1
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1
-
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1
-
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-
1
-
-
1
-
-
695427
Bernstein
Reduced neuronal co-localisati ...
Homo sapiens
Age (Dordr. )
31
11-25
2009
-
-
-
-
-
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3
-
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2
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2
-
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-
-
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-
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-
1
1
-
-
-
695465
Korovkina
Nardilysin convertase regulate ...
Homo sapiens
Am. J. Physiol. Cell Physiol.
296
C433-C440
2009
-
-
1
-
-
-
1
-
-
1
-
-
-
11
-
-
-
-
-
3
-
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-
3
-
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1
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1
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1
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3
-
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-
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-
710043
Ohno
Nardilysin regulates axonal ma ...
Mus musculus
Nat. Neurosci.
12
1506-1513
2009
-
-
-
-
1
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-
1
-
3
-
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3
-
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1
-
3
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1
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1
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3
-
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1
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-
-
-
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-
-
-
1
1
-
-
-
683128
Hiraoka
Ectodomain shedding of TNF-alp ...
Homo sapiens
Biochem. Biophys. Res. Commun.
370
154-158
2008
-
-
1
-
1
-
-
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1
-
1
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2
-
2
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1
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1
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1
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2
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-
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-
-
-
-
683793
Hiraoka
Enhancement of alpha-secretase ...
Homo sapiens
J. Neurochem.
102
1595-1605
2007
-
-
1
-
2
-
1
-
-
1
-
1
-
3
-
-
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1
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1
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2
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1
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2
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1
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1
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1
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1
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1
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683930
Bernstein
Histochemical evidence for wid ...
Homo sapiens
Neuroscience
146
1513-1523
2007
-
-
-
-
-
-
-
-
1
1
-
1
-
4
-
-
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-
-
12
-
-
6
-
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1
1
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1
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12
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669495
Nishi
Nardilysin enhances ectodomain ...
Homo sapiens
J. Biol. Chem.
281
31164-31172
2006
-
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