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Literature summary for 3.4.24.61 extracted from
- Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin alpha1; ADAP1) in neuroblastoma cells (2011), Neurochem. Int., 59, 936-944.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p42IP4 | p42IP4 (centaurin alpha1) enhances the enzymatic activity of NRD 3-4 times. | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| SH-SY5Y cell | NRD is expressed in the neurites of RA-stimulated SHSY5Y cells, and localized in vesicular structures | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Abz-GGGFLRRVGQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| nardilysin | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 34 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | differentiation of SH-SY5Y cells by stimulation with 10 microM retinoic acid (RA) results in upregulation of NRD protein levels, with a 6fold rise after 15 days | up |
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