Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.61 extracted from

  • Bernstein, H.; Stricker, R.; Dobrowolny, H.; Truebner, K.; Bogerts, B.; Reiser, G.
    Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons (2007), Neuroscience, 146, 1513-1523.
    View publication on PubMed
Search for more literature for 3.4.24.61

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information cellular localization in adult and developing brain Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metalloendopeptidase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme interacts with the brain-specific protein p42IP4/centaurin-alpha1, the interactionis regulated by phosphatidylinositol 3,4,5-triphosphate and inositol-1,3,4,5-tetrakisphophate, nardilysin might play a role in brain development, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala neuronal cells Homo sapiens
-
brain neuronal cells, wide distribution in brain Homo sapiens
-
brain stem nuclei, neuronal cells Homo sapiens
-
cerebellum Purkinje neurons and dendrites Homo sapiens
-
hypothalamus neuronal cells Homo sapiens
-
neocortex neuronal cells Homo sapiens
-
neuron in cortical neurons the enzyme is partially co-localized with parvalbumin, but not with calretinin Homo sapiens
-
pituitary gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-neoendorphin + H2O
-
 Homo sapiens ?
-
 ?
dynorphin A + H2O
-
 Homo sapiens ?
-
 ?
Glucagon + H2O
-
 Homo sapiens ?
-
 ?
additional information the enzyme interacts with the brain-specific protein p42IP4/centaurin-alpha1, the interactionis regulated by phosphatidylinositol 3,4,5-triphosphate and inositol-1,3,4,5-tetrakisphophate, nardilysin might play a role in brain development, overview Homo sapiens ?
-
 ?
additional information the metalloendopeptidase cleaves N-terminal Arg or Lys residues of peptides Homo sapiens ?
-
 ?
somatostatin-28 + H2O
-
 Homo sapiens ?
-
 ?