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Literature summary for 3.4.24.61 extracted from

  • Hiraoka, Y.; Yoshida, K.; Ohno, M.; Matsuoka, T.; Kita, T.; Nishi, E.
    Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases (2008), Biochem. Biophys. Res. Commun., 370, 154-158.
    View publication on PubMed
Search for more literature for 3.4.24.61

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of V5-tagged NRDc from a a lentivirus vector in TACE-deficient fibroblasts, co-expression of NRDc with ADAM10, recombinant wild-type NRDc and mutant E235A are synthesized using a Bac-to-Bac baculovirus expression system, co-expression of the C-terminally V5-tagged wild-type enzyme with the TNF-alpha-converting enzyme in COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E235A inactive mutant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens expression of nardilysin synergistically enhances TNF-alpha-converting enzyme-induced TNF-alpha ectodomain-shedding via activation of ADAM proteases ADAM9 and ADAM10, activation is independent of protein kinase C, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information expression of nardilysin synergistically enhances TNF-alpha-converting enzyme-induced TNF-alpha ectodomain-shedding via activation of ADAM proteases ADAM9 and ADAM10, activation is independent of protein kinase C, overview Homo sapiens ?
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 ?
N-(2-(N-methylamino)benzoyl)-GGFLRRVGK(2,4-dinitrophenyl)-NH2 + H2O
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 Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
N-Arginine dibasic convertase
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 Homo sapiens
NRDc
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 Homo sapiens