BRENDA - Enzyme Database
show all sequences of 3.4.24.61

Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex

Gluschankof, P.; Gomez, S.; Morel, A.; Cohen, P.; J. Biol. Chem. 262, 9615-9620 (1987)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
bestatin
strong, 0.05 mM
Rattus norvegicus
Ca2+
1 mM
Rattus norvegicus
Chelating agents
strong
Rattus norvegicus
Co2+
1 mM; strong
Rattus norvegicus
Cu2+
1 mM; strong
Rattus norvegicus
EDTA
10 mM
Rattus norvegicus
EGTA
10 mM
Rattus norvegicus
additional information
diisopropyl fluorophosphate (6 mM); Mg2+ (1 mM
Rattus norvegicus
Zn2+
1 mM; strong
Rattus norvegicus
Organism
Organism
UniProt
Commentary
Textmining
Rattus norvegicus
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
partial
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
additional information
[Tyr18]-pro-oxytocin/neurophysin-(1-18)-NH2, Pro-Glu-D-Arg-Lys-Tyr-NH2, Pro-Glu-Arg-D-Lys-Tyr-NH2
31367
Rattus norvegicus
?
-
-
-
?
Pro-Gln-Arg-Lys-Tyr-NH2 + H2O
-
31367
Rattus norvegicus
Pro-Gln + Arg-Lys-Tyr-NH2
-
31367
Rattus norvegicus
?
Pro-Glu-Arg-Arg-Tyr-NH2 + H2O
-
31367
Rattus norvegicus
Pro-Glu + Arg-Arg-Tyr-NH2
-
31367
Rattus norvegicus
?
Pro-Gly-Arg-Lys-Tyr-NH2 + H2O
-
31367
Rattus norvegicus
Pro-Gly + Arg-Lys-Tyr-NH2
-
31367
Rattus norvegicus
?
Somatostatin-28 + H2O
cleavage on amino side of Arg-Lys doublet
31367
Rattus norvegicus
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
-
-
?
Somatostatin-28 + H2O
cleavage site: Glu12-+-Arg13-Lys14, the term -+- depicts the point of cleavage
31367
Rattus norvegicus
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
-
-
?
Somatostatin-28 + H2O
i.e. octacosapeptide
31367
Rattus norvegicus
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
i.e. model peptide I
31367
Rattus norvegicus
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
i.e. Pro-Arg-Glu-Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
31367
Rattus norvegicus
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
More
endopeptidase of somatostatin-28 convertase complex
Rattus norvegicus
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
peptide I as substrate
Rattus norvegicus
pH Range
pH Minimum
pH Maximum
Commentary
Organism
7.3
9
about half-maximal activity at pH 7.3 and about 90% of maximal activity at pH 9, peptide I as substrate
Rattus norvegicus
8
9
-
Rattus norvegicus
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
4
9
3-15 h, 25% or less loss of activity
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
bestatin
strong, 0.05 mM
Rattus norvegicus
Ca2+
1 mM
Rattus norvegicus
Chelating agents
strong
Rattus norvegicus
Co2+
strong
Rattus norvegicus
Co2+
1 mM
Rattus norvegicus
Cu2+
strong
Rattus norvegicus
Cu2+
1 mM
Rattus norvegicus
EDTA
10 mM
Rattus norvegicus
EGTA
10 mM
Rattus norvegicus
additional information
Mg2+ (1 mM
Rattus norvegicus
additional information
diisopropyl fluorophosphate (6 mM)
Rattus norvegicus
Zn2+
strong
Rattus norvegicus
Zn2+
1 mM
Rattus norvegicus
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
additional information
[Tyr18]-pro-oxytocin/neurophysin-(1-18)-NH2, Pro-Glu-D-Arg-Lys-Tyr-NH2, Pro-Glu-Arg-D-Lys-Tyr-NH2
31367
Rattus norvegicus
?
-
-
-
?
Pro-Gln-Arg-Lys-Tyr-NH2 + H2O
-
31367
Rattus norvegicus
Pro-Gln + Arg-Lys-Tyr-NH2
-
31367
Rattus norvegicus
?
Pro-Glu-Arg-Arg-Tyr-NH2 + H2O
-
31367
Rattus norvegicus
Pro-Glu + Arg-Arg-Tyr-NH2
-
31367
Rattus norvegicus
?
Pro-Gly-Arg-Lys-Tyr-NH2 + H2O
-
31367
Rattus norvegicus
Pro-Gly + Arg-Lys-Tyr-NH2
-
31367
Rattus norvegicus
?
Somatostatin-28 + H2O
cleavage on amino side of Arg-Lys doublet
31367
Rattus norvegicus
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
-
-
?
Somatostatin-28 + H2O
cleavage site: Glu12-+-Arg13-Lys14, the term -+- depicts the point of cleavage
31367
Rattus norvegicus
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
-
-
?
Somatostatin-28 + H2O
i.e. octacosapeptide
31367
Rattus norvegicus
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
i.e. model peptide I
31367
Rattus norvegicus
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
i.e. Pro-Arg-Glu-Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
31367
Rattus norvegicus
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
peptide I as substrate
Rattus norvegicus
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
7.3
9
about half-maximal activity at pH 7.3 and about 90% of maximal activity at pH 9, peptide I as substrate
Rattus norvegicus
8
9
-
Rattus norvegicus
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
4
9
3-15 h, 25% or less loss of activity
Rattus norvegicus
Other publictions for EC 3.4.24.61
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
753298
Yoh
Serum nardilysin, a surrogate ...
Homo sapiens
Clin. Cancer Res.
25
619-628
2019
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
-
-
-
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1
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-
-
-
-
-
-
-
-
-
-
-
753303
Chen
Clinical determination of ser ...
Homo sapiens
Clin. Chim. Acta
494
8-13
2019
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
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1
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1
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-
-
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-
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-
753760
Ikuta
Nardilysin inhibits pancreati ...
Mus musculus
Gut
68
882-892
2019
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
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1
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1
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-
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-
-
-
2
2
-
-
-
754562
Kanda
Nardilysin controls intestina ...
Homo sapiens, Mus musculus
JCI Insight
3
91316
2018
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
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-
1
-
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4
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
755470
Kimura
Nardilysin regulates inflamma ...
Mus musculus
Sci. Rep.
7
43052
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
2
-
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-
2
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
752627
Segretain
Ultrastructural localization ...
Mus musculus
Basic Clin. Androl.
26
5
2016
-
-
-
-
-
-
-
-
2
1
-
-
-
6
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
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2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
753390
Nishi
Nardilysin is required for ma ...
Mus musculus
Diabetes
65
3015-3027
2016
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
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2
-
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-
-
-
-
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-
2
2
-
-
-
734761
Hiraoka
Critical roles of nardilysin i ...
Mus musculus
Nat. Commun.
5
3224
2014
-
-
-
-
-
-
-
-
-
1
-
1
-
7
-
-
-
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-
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1
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2
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
734781
Ohno
Nardilysin prevents amyloid pl ...
Mus musculus
Neurobiol. Aging
35
213-222
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
6
-
-
-
-
-
3
-
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1
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2
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1
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3
-
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1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
733071
Bernstein
Nardilysin in human brain dise ...
Homo sapiens
Amino Acids
45
269-278
2013
-
1
-
-
-
-
-
-
-
-
-
6
-
4
-
-
-
-
-
3
-
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6
-
2
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1
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6
-
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3
-
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6
-
-
-
-
-
-
-
-
-
2
1
1
2
-
-
720003
Li
Identification and Characteria ...
Homo sapiens
J. Biol. Chem.
287
10089-10098
2012
-
-
1
-
5
-
-
-
2
-
-
2
-
1
-
-
1
-
-
-
-
-
2
-
2
-
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1
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5
-
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2
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2
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1
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2
-
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-
-
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-
-
-
-
-
1
1
-
-
-
733727
Kanda
Nardilysin and ADAM proteases ...
Homo sapiens
EMBO Mol. Med.
4
396-411
2012
-
-
-
-
-
-
-
-
1
1
-
1
-
3
-
-
-
-
-
1
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1
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2
-
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1
1
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1
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1
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1
-
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-
-
-
-
-
-
-
1
2
2
1
-
-
718147
Kessler
Antigen processing by nardilys ...
Homo sapiens
Nat. Immunol.
12
45-53
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
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-
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2
-
1
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-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719245
Borrmann
Tubulin potentiates the intera ...
Homo sapiens
Cell Tissue Res.
346
89-98
2011
-
-
1
-
2
-
-
-
2
-
-
1
-
1
-
-
1
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
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1
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2
-
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-
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-
2
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
720552
Borrmann
Retinoic acid-induced upregula ...
Homo sapiens
Neurochem. Int.
59
936-944
2011
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
1
-
-
-
1
-
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-
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-
-
1
-
-
-
-
-
-
-
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-
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1
-
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1
-
1
-
-
-
1
-
-
-
1
-
-
1
-
-
695427
Bernstein
Reduced neuronal co-localisati ...
Homo sapiens
Age (Dordr. )
31
11-25
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
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-
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2
-
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3
-
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2
-
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
695465
Korovkina
Nardilysin convertase regulate ...
Homo sapiens
Am. J. Physiol. Cell Physiol.
296
C433-C440
2009
-
-
1
-
-
-
1
-
-
1
-
-
-
11
-
-
-
-
-
3
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
710043
Ohno
Nardilysin regulates axonal ma ...
Mus musculus
Nat. Neurosci.
12
1506-1513
2009
-
-
-
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
3
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
683128
Hiraoka
Ectodomain shedding of TNF-alp ...
Homo sapiens
Biochem. Biophys. Res. Commun.
370
154-158
2008
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683793
Hiraoka
Enhancement of alpha-secretase ...
Homo sapiens
J. Neurochem.
102
1595-1605
2007
-
-
1
-
2
-
1
-
-
1
-
1
-
3
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
1
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683930
Bernstein
Histochemical evidence for wid ...
Homo sapiens
Neuroscience
146
1513-1523
2007
-
-
-
-
-
-
-
-
1
1
-
1
-
4
-
-
-
-
-
12
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
12
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669495
Nishi
Nardilysin enhances ectodomain ...
Homo sapiens
J. Biol. Chem.
281
31164-31172
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669940
Stricker
Interaction of the brain-speci ...
Rattus norvegicus
J. Neurochem.
98
343-354
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667308
Ma
Subcellular localization of na ...
Mus musculus
Arch. Biochem. Biophys.
434
187-194
2005
-
-
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667791
Chow
Nardilysin facilitates complex ...
Rattus norvegicus
Biochim. Biophys. Acta
1723
292-301
2005
1
-
-
-
-
-
-
-
-
-
2
-
-
10
-
-
-
-
-
4
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668421
Fontes
Miniglucagon (MG)-generating e ...
Mus musculus, Rattus norvegicus
Endocrinology
146
702-712
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
3
-
-
2
2
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667300
Ma
Nuclear shuttling of the pepti ...
Mus musculus
Arch. Biochem. Biophys.
422
153-160
2004
-
-
-
-
1
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650203
Chow
Nardilysin cleaves peptides at ...
Mus musculus
Biochemistry
42
2239-2244
2003
-
-
1
-
-
-
2
17
-
1
1
1
-
1
-
-
1
-
-
-
-
-
10
-
1
-
-
-
24
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
17
-
1
1
1
-
-
-
1
-
-
-
-
10
-
-
-
-
24
-
-
-
-
-
-
-
-
-
-
649460
Ma
The use of proteolysis to stud ...
Mus musculus
Arch. Biochem. Biophys.
401
198-204
2002
-
-
-
-
-
-
2
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652006
Chow
Studies on the subsite specifi ...
Rattus norvegicus
J. Biol. Chem.
275
19545-19551
2000
-
-
-
-
-
-
-
43
-
1
-
-
-
6
-
-
1
-
-
1
-
-
77
-
2
-
-
-
42
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
43
-
1
-
-
-
-
-
1
-
1
-
-
77
-
-
-
-
42
-
-
-
-
-
-
-
-
-
-
649420
Csuhai
Kinetic analysis of spermine b ...
Rattus norvegicus
Arch. Biochem. Biophys.
362
291-300
1999
-
-
-
-
-
-
2
7
2
1
-
-
-
3
-
-
1
-
-
-
-
-
1
-
2
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
7
2
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
649325
Foulon
NRD convertase and aminopeptid ...
Rattus norvegicus
Ann. Endocrinol. (Paris)
58
357-364
1997
-
-
1
-
-
-
5
-
-
1
1
-
-
5
-
-
1
-
-
-
-
-
3
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
5
-
-
-
1
1
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
31369
Cohen
N-arginine dibasic convertase ...
Rattus norvegicus
Methods Enzymol.
248
703-716
1995
-
-
1
-
-
-
14
12
-
-
7
-
-
1
-
-
1
-
-
6
-
-
14
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
20
-
12
-
-
7
-
-
-
-
1
-
6
-
-
14
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
31365
Chesneau
Isolation and characterization ...
Rattus norvegicus
J. Biol. Chem.
269
2056-2061
1994
-
-
-
-
-
-
14
12
1
2
2
-
-
1
-
-
1
-
-
7
-
-
20
1
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
21
-
12
1
2
2
-
-
-
-
1
-
7
-
-
20
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
31368
Pierotti
N-Arginine dibasic convertase, ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
91
6078-6082
1994
-
-
1
-
-
-
-
-
-
3
-
-
-
7
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
31370
Cohen
Somatostatin-28 and pro-ocytoc ...
Rattus norvegicus
Biochimie
70
17-23
1988
-
-
-
-
-
-
-
-
2
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
31367
Gluschankof
Enzymes that process somatosta ...
Rattus norvegicus
J. Biol. Chem.
262
9615-9620
1987
-
-
-
-
-
-
9
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
9
-
1
1
-
-
-
1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
1
-
1
-
-
9
-
1
-
-
-
1
2
1
-
-
-
-
-
-
-
31366
Gomez
The somatostatin-28 convertase ...
Rattus norvegicus
J. Biol. Chem.
260
10541-10545
1985
-
-
-
-
-
-
-
1
3
-
1
-
-
1
-
-
1
-
-
2
-
-
7
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
-
1
-
-
-
-
1
-
2
-
-
7
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-