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Literature summary for 3.4.24.61 extracted from

  • Gomez, S.; Gluschankof, P.; Morel, A.; Cohen, P.
    The somatostatin-28 convertase of rat brain cortex is associated with secretory granule membranes (1985), J. Biol. Chem., 260, 10541-10545.
    View publication on PubMed
Search for more literature for 3.4.24.61

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0055
-
 Somatostatin-28
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
additional information subcellular distribution Rattus norvegicus
-
-
secretory granule membrane internal face of granule membrane Rattus norvegicus 30667
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
hypothalamus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information strict specificity depending upon sequence around Arg-Lys-pair Rattus norvegicus ?
-
 ?
additional information no substrates are dodecapeptide fragment of corticotropin-releasing factor (i.e. Ala-Tyr-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2) Rattus norvegicus ?
-
 ?
peptide I + H2O i.e. Pro-Arg-Glu-Arg-Lys-Ala-Gly-Ala-Lys-Asn125I-Tyr-NH2 Rattus norvegicus Pro-Arg-Glu-Arg-Lys + Ala-Gly-Ala-Lys-Asn-Tyr-NH2 i.e. peptide II ?
Peptide III + H2O i.e. Pro-Arg-Glu-Arg-Arg-Ala-Gly-Ala-Lys-Asn-Tyr-NH2 Rattus norvegicus Pro-Arg-Glu-Arg + Arg-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
 ?
Somatostatin-28 + H2O cleavage site: Glu12-+-Arg13-Lys14, the term -+- depicts the point of cleavage Rattus norvegicus Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
 ?
Somatostatin-28 + H2O i.e. octacosapeptide Rattus norvegicus Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
 ?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O i.e. desiodinated peptide I Rattus norvegicus Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus