Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
expression in Escherichia coli | Mus musculus |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methyl [(2S)-2-(5-[5-[4-([(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl]amino)phenyl]pentyl]-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate | - |
Homo sapiens | |
methyl [(2S)-2-[4-([5-[4-([(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl]amino)phenyl]pentyl]oxy)phenyl]-3-(quinolin-3-yl)butyl]carbamate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
insulin + H2O | Homo sapiens | in HEK cells the enzyme has little impact on insulin clearance | ? | - |
? | |
insulin + H2O | Mus musculus | the enzyme is implicated in proteolysis of insulin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14735 | - |
- |
Mus musculus | Q9JHR7 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Glucagon + H2O | - |
Homo sapiens | ? | - |
? | |
insulin + H2O | - |
Homo sapiens | ? | - |
? | |
insulin + H2O | - |
Mus musculus | ? | - |
? | |
insulin + H2O | in HEK cells the enzyme has little impact on insulin clearance | Homo sapiens | ? | - |
? | |
insulin + H2O | the enzyme is implicated in proteolysis of insulin | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Homo sapiens |
IDE | - |
Mus musculus |
Insulin-degrading enzyme | - |
Homo sapiens |
Insulin-degrading enzyme | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000015 | - |
37°C, pH 7.5 | Homo sapiens | methyl [(2S)-2-[4-([5-[4-([(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl]amino)phenyl]pentyl]oxy)phenyl]-3-(quinolin-3-yl)butyl]carbamate | |
0.000018 | - |
37°C, pH 7.5 | Homo sapiens | methyl [(2S)-2-(5-[5-[4-([(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl]amino)phenyl]pentyl]-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme has a minimal role in insulin metabolism in vivo. It may be more important in helping regulate amylin clearance | Homo sapiens |
physiological function | the enzyme is implicated in proteolysis of insulin | Mus musculus |