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Literature summary for 3.4.24.56 extracted from

  • Kummer, M.P.; Huelsmann, C.; Hermes, M.; Axt, D.; Heneka, M.T.
    Nitric Oxide Decreases the Enzymatic Activity of Insulin Degrading Enzyme in APP/PS1 Mice (2012), J. Neuroimmune Pharmacol., 7, 165-172.
    View publication on PubMed
Search for more literature for 3.4.24.56

Cloned(Commentary)

Cloned (Comment) Organism
recombinantly expressed Mus musculus
recombinantly expressed Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
nitric oxide amyloid beta peptide degradation by IDE is inhibited by NO donor Sin-1 Homo sapiens
nitric oxide incubation with NO donor Sin-1 results in a strong reduction of IDE activity. In vivo the activity of insulin-degrading enzyme is lowered in APP/PS1 mice, but not in APP/PS1/NOS2(-/-) mice Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-RPPGFSAFK-2,4-dinitrophenyl + H2O
-
 Homo sapiens ?
-
 ?
2-aminobenzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl + H2O
-
 Mus musculus 2-aminobenzoyl-GGFLR + KHGQ-ethylenediamine-2,4-dinitrophenyl
-
 ?
amyloid beta peptide + H2O
-
 Mus musculus ?
-
 ?
amyloid beta peptide + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
IDE
-
 Mus musculus
IDE
-
 Homo sapiens
Insulysin
-
 Mus musculus
Insulysin
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus
7.5
-
 assay at Homo sapiens